| Accession | ARO:3000794 |
| Synonym(s) | yegO |
| CARD Short Name | mdtC |
| Definition | MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | aminocoumarin antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Escherichia colig+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterococcus faecaliswgs, Enterococcus faeciumwgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Serratia marcescenswgs, Shigella boydiig+wgs, Shigella dysenteriaewgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Staphylococcus aureuswgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + aminocoumarin antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + novobiocin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Nagakubo S, et al. 2002. J Bacteriol 184(15): 4161-4167. The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. (PMID 12107133) |
Prevalence of mdtC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.06% | 0% |
| Citrobacter amalonaticus | 100% | 0% | 87.5% | 0% |
| Citrobacter freundii | 78.46% | 0% | 57.47% | 0% |
| Citrobacter koseri | 100% | 0% | 45.56% | 0% |
| Citrobacter portucalensis | 100% | 0% | 84% | 0% |
| Citrobacter werkmanii | 28.57% | 0% | 14.29% | 0% |
| Citrobacter youngae | 50% | 0% | 14.29% | 0% |
| Enterobacter cloacae | 2.27% | 0% | 2.27% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.35% | 0% |
| Enterobacter kobei | 0% | 0% | 0.82% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.05% | 0% |
| Enterococcus faecium | 0% | 0% | 0.04% | 0% |
| Escherichia albertii | 100% | 0% | 96.55% | 0% |
| Escherichia coli | 61.29% | 0.04% | 74.71% | 0% |
| Escherichia fergusonii | 100% | 0.4% | 41.54% | 0% |
| Escherichia marmotae | 100% | 0% | 69.05% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.31% | 0% |
| Klebsiella michiganensis | 0% | 0% | 0.32% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.36% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.36% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.02% | 0% |
| Salmonella enterica | 0% | 0% | 0.05% | 0% |
| Serratia marcescens | 0% | 0% | 0.3% | 0% |
| Shigella boydii | 100% | 0% | 94.62% | 0% |
| Shigella dysenteriae | 0% | 0% | 67.86% | 0% |
| Shigella flexneri | 100% | 0% | 80.72% | 0% |
| Shigella sonnei | 100% | 0% | 96% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 1800