Accession | ARO:3000915 |
Synonym(s) | CAZ-9 |
Definition | TEM-46 is an extended-spectrum beta-lactamase that has been found in clinical isolates. |
AMR Gene Family | TEM beta-lactamase |
Drug Class | penam, monobactam, penem, cephalosporin |
Resistance Mechanism | antibiotic inactivation |
Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + beta-lactam antibiotic + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactamase + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + penam [Drug Class] + cephem + class A beta-lactamase + monobactam [Drug Class] + penem [Drug Class] + ampicillin [Antibiotic] + cephalosporin [Drug Class] |
Parent Term(s) | 1 ontology terms | Show + TEM beta-lactamase [AMR Gene Family] |
Publications | Chanal-Claris C, et al. 1997. Antimicrob Agents Chemother 41(3): 715-716. Novel extended-spectrum TEM-type beta-lactamase from an Escherichia coli isolate resistant to ceftazidime and susceptible to cephalothin. (PMID 9056022) |