| Accession | ARO:3002132 |
| CARD Short Name | DHA-1 |
| Definition | DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica. |
| AMR Gene Family | DHA beta-lactamase |
| Drug Class | cephamycin, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter indicusp, Citrobacter amalonaticusp, Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensisp, Citrobacter youngaewgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+gi, Morganella morganiig+wgs, Proteus mirabilisg+p+wgs+gi, Proteus vulgariswgs, Providencia rettgerig+p+wgs, Providencia stuartiig+gi, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescenswgs, Shigella boydiiwgs, Shigella flexneriwgs, Shigella sonneip+gi, Vibrio choleraewgs |
| Resistomes with Sequence Variants | Acinetobacter indicusp, Citrobacter amalonaticusp, Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensisp, Citrobacter youngaewgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+gi, Morganella morganiig+wgs, Proteus mirabilisg+p+wgs+gi, Proteus vulgariswgs, Providencia rettgerig+p+wgs, Providencia stuartiig+gi, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescenswgs, Shigella boydiiwgs, Shigella flexneriwgs, Shigella sonneip+gi, Vibrio choleraewgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + hydrolysis of antibiotic conferring resistance + antibiotic inactivation enzyme + beta-lactam antibiotic + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + cephamycin [Drug Class] + cephalosporin [Drug Class] + class C beta-lactamase |
| Parent Term(s) | 1 ontology terms | Show + DHA beta-lactamase [AMR Gene Family] |
| Sub-Term(s) | 1 ontology terms | Show + vaborbactam [Adjuvant] is_small_molecule_inhibitor |
| Publications | Barnaud G, et al. 1998. Antimicrob Agents Chemother 42(9): 2352-2358. Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii. (PMID 9736562) |
Prevalence of DHA-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter indicus | 0% | 1.89% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 0% | 0% |
| Citrobacter freundii | 0% | 1.54% | 3.09% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 1.47% | 0% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 0.79% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter cloacae | 0% | 0% | 2.88% | 0% |
| Enterobacter hormaechei | 0% | 1.03% | 1.81% | 0% |
| Enterobacter kobei | 0% | 0.69% | 2.18% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.36% | 0% |
| Escherichia coli | 0.05% | 0.04% | 0.31% | 0% |
| Klebsiella aerogenes | 0% | 1.09% | 0.28% | 0% |
| Klebsiella michiganensis | 0% | 1.14% | 1.33% | 0% |
| Klebsiella oxytoca | 2.56% | 0% | 1.26% | 0% |
| Klebsiella pneumoniae | 0.59% | 1.31% | 2.41% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.69% | 4.08% | 0% |
| Leclercia adecarboxylata | 7.14% | 0% | 0% | 50% |
| Morganella morganii | 23.08% | 0% | 15.34% | 0% |
| Proteus mirabilis | 2.75% | 1.25% | 1.82% | 3.7% |
| Proteus vulgaris | 0% | 0% | 5.56% | 0% |
| Providencia rettgeri | 2.94% | 5.41% | 0.64% | 0% |
| Providencia stuartii | 6.25% | 0% | 0% | 33.33% |
| Raoultella planticola | 0% | 2.33% | 2.56% | 0% |
| Salmonella enterica | 0.13% | 0.77% | 0.53% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Shigella boydii | 0% | 0% | 1.11% | 0% |
| Shigella flexneri | 0% | 0% | 0.16% | 0% |
| Shigella sonnei | 0% | 0.97% | 0% | 4.76% |
| Vibrio cholerae | 0% | 0% | 0.06% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700