| Accession | ARO:3002931 |
| Synonym(s) | vanSA vanS-A |
| CARD Short Name | vanS_in_vanA_cl |
| Definition | Also known as vanSA, is a vanS variant found in the vanA gene cluster. |
| AMR Gene Family | glycopeptide resistance gene cluster, vanS |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Enterococcus aviump, Enterococcus faecalisp, Enterococcus faeciump |
| Resistomes with Sequence Variants | Enterococcus aviump, Enterococcus faecalisp+wgs, Enterococcus faeciumg+p+wgs, Klebsiella pneumoniaewgs, Staphylococcus aureusg+p+wgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + restructuring of bacterial cell wall conferring antibiotic resistance + antibiotic molecule + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic resistance gene cluster, cassette, or operon + glycopeptide antibiotic [Drug Class] + gene(s) or protein(s) associated with a glycopeptide resistance cluster + glycopeptide resistance gene cluster [AMR Gene Family] + VanS-VanR two-component regulatory system + teicoplanin [Antibiotic] + vancomycin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) Arthur M, et al. 1993. J Bacteriol 175(1): 117-127. Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (PMID 8380148) Hughes CS, et al. 2017. Biochim. Biophys. Acta : Characterisation of the selective binding of antibiotics vancomycin and teicoplanin by the VanS receptor regulating type A vancomycin resistance in the enterococci. (PMID 28511809) |
Prevalence of vanS gene in vanA cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus avium | 0% | 33.33% | 0% | 0% |
| Enterococcus faecalis | 0% | 2.46% | 0.94% | 0% |
| Enterococcus faecium | 1.59% | 10.1% | 15.51% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Staphylococcus aureus | 0.7% | 0.19% | 0.03% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700