| Accession | ARO:3003250 |
| CARD Short Name | bcrC |
| Definition | The bcrC gene product (BcrC) is an undecaprenyl pyrophosphate phosphatase originally isolated from Bacillus subtilis. When overexpressed it can confer resistance to bacitracin. |
| AMR Gene Family | undecaprenyl pyrophosphate related proteins |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic mixture + peptide antibiotic [Drug Class] + restructuring of bacterial cell wall conferring antibiotic resistance + bacitracin [Antibiotic] + protein(s) conferring antibiotic resistance via molecular bypass |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_antibiotic bacitracin F [Antibiotic] + confers_resistance_to_antibiotic bacitracin B [Antibiotic] + confers_resistance_to_antibiotic bacitracin A [Antibiotic] + undecaprenyl pyrophosphate related proteins [AMR Gene Family] |
| Publications | Bernard R, et al. 2005. J Biol Chem 280(32): 28852-28857. BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance. (PMID 15946938) |
Prevalence of bcrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 350