| Accession | ARO:3003361 |
| CARD Short Name | Pros_EFTu_GE2A |
| Definition | Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A. |
| AMR Gene Family | elfamycin resistant EF-Tu |
| Drug Class | elfamycin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Klebsiella pneumoniaewgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistant gene variant or mutant + Antibiotic resistant EF-Tu + elfamycin antibiotic [Drug Class] + elfamycin resistant EF-Tu [AMR Gene Family] + cyclic thiazolyl peptide elfamycin |
| Parent Term(s) | 3 ontology terms | Show + derives_from elongation factor Tu + confers_resistance_to_antibiotic GE2270A [Antibiotic] + Planobispora rosea EF-Tu mutants conferring resistance to elfamycin |
| Publications | Hogg T, et al. 2002. Curr Protein Pept Sci 3(1): 121-131. Inhibitory mechanisms of antibiotics targeting elongation factor Tu. (PMID 12370016) Sosio M, et al. 1996. Mol Microbiol 22(1): 43-51. An elongation factor Tu (EF-Tu) resistant to the EF-Tu inhibitor GE2270 in the producing organism Planobispora rosea. (PMID 8899707) |
Prevalence of Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 700
PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).| Mutation | Mutation type | PubMed |
|---|---|---|
| G261S | single resistance variant | curation underway |
| V278A | single resistance variant | curation underway |
| G279A | single resistance variant | curation underway |
| V295C | single resistance variant | curation underway |
| Curator | Description | Most Recent Edit |
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