Accession | ARO:3003724 |
Synonym(s) | vanW-I vanWI |
CARD Short Name | vanW_in_vanI_cl |
Definition | Also known as vanWI, is a vanW variant found in the vanI gene cluster. |
AMR Gene Family | glycopeptide resistance gene cluster, vanW |
Drug Class | glycopeptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Resistomes with Sequence Variants | Actinomyces viscosusg+wgs, Anaerostipes hadrusg+wgs, Bacillus anthracisg+wgs, Bacillus cereusg+p+wgs, Bacillus halotoleransg+wgs, Bacillus pumiluswgs, Bacillus subtilisg+wgs, Bacillus tequilensisg+wgs, Bacillus thuringiensisg+p+wgs, Brevibacillus brevisg+wgs, Brevibacillus laterosporusg+wgs, Christensenella minutag+wgs, Clostridium botulinumg+wgs, Clostridium butyricumg+wgs, Clostridium perfringensg+wgs, Clostridium septicumg+wgs, Clostridium sporogenesg+wgs, Clostridium tetanig+wgs, Comamonas testosteroniwgs, Corynebacterium amycolatumg+wgs, Corynebacterium diphtheriaeg+wgs, Corynebacterium imitansg+wgs, Corynebacterium jeikeiumg+wgs, Corynebacterium matruchotiig+wgs, Corynebacterium pseudotuberculosisg+wgs, Corynebacterium ulceransg+wgs, Corynebacterium urealyticumg+wgs, Corynebacterium ureicelerivoransg+wgs, Deinococcus radioduransg+wgs, Dysosmobacter welbionisg+wgs, Eggerthella lentag+wgs, Enterobacter roggenkampiiwgs, Enterocloster clostridioformisg+wgs, Erysipelatoclostridium ramosumg+wgs, Glutamicibacter creatinolyticusg, Gordonibacter urolithinfaciensg+wgs, Herbinix luporumg+wgs, Inquilinus limosuswgs, Klebsiella pneumoniaewgs, Lachnoclostridium phocaeenseg, Massilistercora timonensisg, Megasphaera stantoniig+wgs, Mobiluncus mulieriswgs, Nocardia asiaticawgs, Nocardia exalbidawgs, Nocardia farcinicag+p+wgs, Paenibacillus mucilaginosusg+wgs, Paeniclostridium sordelliig+wgs, Parvimonas micrag+wgs, Peptacetobacter hiranonisg+wgs, Peptoniphilus hareig+wgs, Phoenicibacter congonensisg, Rhodococcus pyridinivoransg+wgs, Rhodococcus rhodochrousg+wgs, Roseburia hominisg+wgs, Vibrio vulnificuswgs |
Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + glycopeptide antibiotic [Drug Class] + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic resistance gene cluster, cassette, or operon + gene(s) or protein(s) associated with a glycopeptide resistance cluster + glycopeptide resistance gene cluster [AMR Gene Family] + teicoplanin [Antibiotic] + vancomycin [Antibiotic] |
Parent Term(s) | 2 ontology terms | Show |
Publications | Kalan L, et al. 2009. Antimicrob. Agents Chemother. 53(7):2841-5 Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51. (PMID 19414574) Nonaka H, et al. 2006. J. Bacteriol. 188(6):2262-74 Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195. (PMID 16513756) |
Prevalence of vanW gene in vanI cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
---|---|---|---|---|---|
Actinomyces viscosus | 100% | 0% | 100% | 0% | 0% |
Anaerostipes hadrus | 100% | 0% | 100% | 0% | 0% |
Bacillus anthracis | 100% | 0% | 100.44% | 0% | 0% |
Bacillus cereus | 100% | 0.3% | 103.99% | 0% | 0% |
Bacillus halotolerans | 100% | 0% | 97.3% | 0% | 0% |
Bacillus pumilus | 0% | 0% | 0.56% | 0% | 0% |
Bacillus subtilis | 87.1% | 0% | 96.24% | 0% | 0% |
Bacillus tequilensis | 100% | 0% | 100% | 0% | 0% |
Bacillus thuringiensis | 100% | 0.13% | 100.35% | 0% | 0% |
Brevibacillus brevis | 100% | 0% | 100% | 0% | 0% |
Brevibacillus laterosporus | 100% | 0% | 100% | 0% | 0% |
Christensenella minuta | 100% | 0% | 120% | 0% | 0% |
Clostridium botulinum | 97.01% | 0% | 100% | 0% | 0% |
Clostridium butyricum | 66.67% | 0% | 98.04% | 0% | 0% |
Clostridium perfringens | 100% | 0% | 99.76% | 0% | 0% |
Clostridium septicum | 100% | 0% | 100% | 0% | 0% |
Clostridium sporogenes | 100% | 0% | 100.85% | 0% | 0% |
Clostridium tetani | 100% | 0% | 100% | 0% | 0% |
Comamonas testosteroni | 0% | 0% | 7.14% | 0% | 0% |
Corynebacterium amycolatum | 100% | 0% | 100% | 0% | 0% |
Corynebacterium diphtheriae | 100% | 0% | 100% | 0% | 0% |
Corynebacterium imitans | 100% | 0% | 100% | 0% | 0% |
Corynebacterium jeikeium | 100% | 0% | 100% | 0% | 0% |
Corynebacterium matruchotii | 100% | 0% | 100% | 0% | 0% |
Corynebacterium pseudotuberculosis | 100% | 0% | 100% | 0% | 0% |
Corynebacterium ulcerans | 100% | 0% | 100% | 0% | 0% |
Corynebacterium urealyticum | 100% | 0% | 100% | 0% | 0% |
Corynebacterium ureicelerivorans | 100% | 0% | 100% | 0% | 0% |
Deinococcus radiodurans | 52% | 0% | 100% | 0% | 0% |
Dysosmobacter welbionis | 100% | 0% | 100% | 0% | 0% |
Eggerthella lenta | 100% | 0% | 98.96% | 0% | 0% |
Enterobacter roggenkampii | 0% | 0% | 0.36% | 0% | 0% |
Enterocloster clostridioformis | 100% | 0% | 118.6% | 0% | 0% |
Erysipelatoclostridium ramosum | 100% | 0% | 100% | 0% | 0% |
Glutamicibacter creatinolyticus | 100% | 0% | 0% | 0% | 0% |
Gordonibacter urolithinfaciens | 100% | 0% | 100% | 0% | 0% |
Herbinix luporum | 100% | 0% | 100% | 0% | 0% |
Inquilinus limosus | 0% | 0% | 50% | 0% | 0% |
Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% | 0% |
Lachnoclostridium phocaeense | 100% | 0% | 0% | 0% | 0% |
Massilistercora timonensis | 100% | 0% | 0% | 0% | 0% |
Megasphaera stantonii | 100% | 0% | 100% | 0% | 0% |
Mobiluncus mulieris | 0% | 0% | 97.06% | 0% | 0% |
Nocardia asiatica | 0% | 0% | 100% | 0% | 0% |
Nocardia exalbida | 0% | 0% | 100% | 0% | 0% |
Nocardia farcinica | 75% | 8.33% | 100% | 0% | 0% |
Paenibacillus mucilaginosus | 100% | 0% | 100% | 0% | 0% |
Paeniclostridium sordellii | 100% | 0% | 100% | 0% | 0% |
Parvimonas micra | 100% | 0% | 100% | 0% | 0% |
Peptacetobacter hiranonis | 100% | 0% | 150% | 0% | 0% |
Peptoniphilus harei | 100% | 0% | 100% | 0% | 0% |
Phoenicibacter congonensis | 100% | 0% | 0% | 0% | 0% |
Rhodococcus pyridinivorans | 100% | 0% | 100% | 0% | 0% |
Rhodococcus rhodochrous | 100% | 0% | 100% | 0% | 0% |
Roseburia hominis | 100% | 0% | 100% | 0% | 0% |
Vibrio vulnificus | 0% | 0% | 0.41% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 50
Curator | Description | Most Recent Edit |
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