eatAv

Accession ARO:3003761
CARD Short NameeatAv
DefinitioneatAv is a mutated form of the wildtype eatA ABC-F subfamily protein isolated from Enterococcus faecium conferring resistance to lincosamides, streptogramin A's and pleuromutilins (LSaP phenotype).
AMR Gene FamilyMiscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Drug Classpleuromutilin antibiotic
Resistance Mechanismantibiotic target protection
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic pleuromutilin [Antibiotic]
+ Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins [AMR Gene Family]
Publications

Isnard C, et al. 2013. Antimicrob. Agents Chemother. 57(9):4463-9 Genetic basis for in vitro and in vivo resistance to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) in Enterococcus faecium. (PMID 23836170)

Lam MM, et al. 2012. J. Bacteriol. 194(9):2334-41 Comparative analysis of the first complete Enterococcus faecium genome. (PMID 22366422)

Resistomes

Prevalence of eatAv among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1000

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:


>gb|AGQ48857.1|+|eatAv [Enterococcus faecium]
MSKIEIKNLTFGYDSQGTLLFEQANLNFDTQWKLGLIGRNGRGKTTLLNILQNKLPYQGQ
VIHQQEFAYFPQQTKDKERLTYYVLNDITDFEIWEIERELQLMQTDPEILWREFSTLSGG
EKTKVLLALLFVDDTHFPLIDEPTNHLDISGRKQVAAYLKKKKQGFIVVSHDRGFIDEVV
DHVLAIEKSQLELYQGNFSIYEEQKKLRDEFEMAQNEKLKKEVSRLKKTAAEKAEWSRSR
EGDKTKKQVGFIDTESRRVNKGAVGADAARTMKRSKAIVNRMETQISEKEKLLKDIEYID
SLTMNSQASHHKRLLSVEDLQLGYENLLFEPIHFTIEPHQRVAISGPNGAGKSSIIHYLL
GAFNGKVIGEKYQPKHLSISYASQNYEDNRGTLAEFAEKNQVDYQAFLNNLRKLGMERDV
FHNKIEQMSMGQRKKVELAKSLSQPAELYIWDEPLNYLDVFNQEQLEQLILNVKPAMLLV
EHDQTFLDKVSTEIISLERI



>gb|KF010779.1|+|1-1503|eatAv [Enterococcus faecium]
ATGTCTAAAATCGAAATAAAAAATCTGACATTCGGCTACGACAGCCAAGGCACATTATTATTTGAACAAGCAAATCTAAATTTTGACACA
CAATGGAAACTAGGACTTATCGGACGAAACGGTCGAGGAAAGACAACTTTACTGAATATTCTACAAAACAAACTACCTTATCAAGGGCAA
GTAATCCATCAGCAAGAATTTGCCTATTTCCCGCAACAGACAAAAGATAAAGAACGTTTAACCTATTACGTGTTAAATGATATTACGGAT
TTTGAGATATGGGAAATCGAAAGAGAGCTCCAATTGATGCAAACAGATCCTGAAATCTTATGGAGAGAATTCAGCACACTATCGGGGGGA
GAGAAGACAAAAGTCCTACTGGCACTTTTATTTGTGGATGACACTCATTTCCCGTTAATCGATGAACCAACGAATCATTTGGATATCTCT
GGTAGAAAACAAGTAGCGGCTTATTTGAAAAAGAAAAAACAAGGCTTCATCGTGGTCAGCCATGACCGGGGATTTATCGATGAAGTAGTG
GACCATGTTTTAGCAATCGAAAAAAGTCAACTGGAACTTTATCAAGGGAATTTCTCTATCTATGAAGAACAGAAAAAACTTCGTGATGAA
TTTGAAATGGCTCAAAATGAAAAATTGAAAAAAGAAGTCAGTAGGCTAAAGAAAACAGCAGCTGAAAAAGCCGAATGGTCTCGTTCCCGA
GAAGGAGATAAAACAAAGAAACAAGTCGGATTCATCGATACTGAATCTAGACGAGTGAATAAAGGAGCAGTGGGTGCTGATGCTGCACGG
ACGATGAAACGATCCAAAGCAATCGTGAATCGGATGGAGACCCAGATCAGCGAGAAAGAAAAACTATTAAAAGATATCGAATATATCGAT
TCTTTGACGATGAATAGCCAAGCGTCTCACCATAAGCGACTTTTAAGCGTAGAAGATCTTCAATTAGGGTATGAAAATCTGTTATTCGAG
CCAATTCATTTTACAATCGAGCCTCATCAGCGGGTGGCGATTTCAGGTCCTAACGGTGCAGGAAAGTCATCCATTATCCATTATCTTCTG
GGGGCATTCAACGGCAAGGTTATAGGAGAAAAATACCAGCCAAAACATCTGAGCATTAGTTATGCAAGCCAAAATTATGAAGACAATCGA
GGAACGTTGGCGGAATTTGCAGAGAAAAACCAAGTAGACTACCAAGCATTTTTGAACAACCTCCGAAAGCTTGGGATGGAAAGAGATGTT
TTTCATAACAAGATCGAGCAGATGAGTATGGGCCAACGGAAAAAAGTGGAATTGGCTAAATCTTTATCACAGCCAGCTGAACTATATATA
TGGGATGAACCATTGAATTATTTGGATGTCTTCAATCAAGAACAATTAGAACAACTGATCTTGAACGTGAAACCTGCCATGTTACTAGTG
GAACATGATCAAACCTTCCTGGATAAAGTATCTACTGAGATTATTTCTCTTGAGAGAATCTAA