tetA(46)

Accession ARO:3004032
CARD Short NametetA(46)
DefinitiontetA(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Warburton PJ, et al. 2013. J. Antimicrob. Chemother. 68(1):17-22 TetAB46, a predicted heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. (PMID 22941900)

Resistomes

Prevalence of tetA(46) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1100


>gb|AET10444.1|+|tetA(46) [Streptococcus australis]
MIRAIWEYIRERKWRYVKIAMVLILYDYTLLIPTQVIQRLVDHLSQQTLTQSNFVWDMVLLVGSAILNYLTAFYWQLRLFQSSVHFKATL
QGQAFRKLVAMRRPFFEKFRSGDLLTRFTTDVDGMADMAGYGMMVLLFGGGLFAFIIPTMFFISWQLTLISFIPMIFLVVSTYFLSRKQE
EYVEQNREAVAQLNDEVLESIEGIRVMRAYSRRDQQVKQFQKKTASLSKTGDKIASIQYSFGPLALLFIGFSTVLLLLFGGQSLASGQLS
LGKLLALQLYLVFLIEPMWMMTDLILVYQTGQMSYKKLKEVIDETDDLEPDGTHYLEQIDSVEFKDYSFSYPGAERKSLSGIDWTIQRGQ
TVGIVGRTGAGKTTLVRQFLRQYPVGEGEFLVNQQPIVDYNRHSIEEKIGYVSQEHILFSKSIRENIALGKKGASQEDLMEAVAQAAFAD
DLERMSHGMDTLIGEKGVSVSGGQKQRISLARAFLRDADLLLLDDSLSAVDAKTEQAIIDTIQKERKDKTTIIVSHRLSAVHQADWIIVL
DQGQIVEEGRASDLLAQEGWYYEQYQRQQKQEGE


>gb|HQ652506.1|+|374-2098|tetA(46) [Streptococcus australis]
ATGATCAGAGCTATTTGGGAGTATATCAGGGAGCGCAAGTGGCGATATGTGAAGATCGCTATGGTACTGATTCTTTATGATTACACTTTA
TTGATCCCGACGCAAGTCATTCAGCGCTTAGTGGATCATTTGAGTCAGCAGACGCTGACGCAATCGAACTTTGTATGGGATATGGTCCTC
TTGGTGGGATCAGCCATCCTCAATTACCTGACGGCTTTTTATTGGCAGTTGCGACTCTTTCAGTCGTCAGTCCATTTCAAGGCGACCCTT
CAGGGACAAGCTTTTCGTAAGCTAGTAGCTATGCGGCGTCCCTTTTTTGAGAAATTTCGCTCAGGGGACCTCTTGACGCGCTTTACGACG
GATGTGGATGGCATGGCCGATATGGCTGGTTACGGGATGATGGTGCTCCTGTTTGGCGGTGGCTTGTTTGCCTTTATTATTCCGACCATG
TTTTTCATTTCTTGGCAATTAACCTTGATTTCCTTTATTCCCATGATCTTCCTTGTCGTCTCTACCTATTTTTTGAGTAGAAAGCAGGAG
GAGTATGTTGAGCAAAACCGGGAAGCGGTTGCTCAGTTGAACGATGAAGTCTTGGAGTCCATCGAAGGGATCCGGGTCATGCGGGCCTAT
AGTAGACGGGATCAGCAGGTCAAACAGTTTCAGAAGAAAACGGCTAGTCTATCCAAAACAGGGGACAAAATTGCTTCTATCCAATATTCT
TTTGGCCCCTTAGCCCTGTTGTTTATTGGATTCTCGACAGTCTTGCTCCTGCTATTTGGAGGACAGTCCCTAGCAAGTGGGCAGTTGAGC
CTTGGCAAGCTATTGGCCTTGCAACTGTATTTGGTCTTTTTAATTGAGCCTATGTGGATGATGACGGACCTGATCTTGGTCTATCAGACA
GGGCAAATGTCCTATAAAAAACTAAAAGAAGTGATTGATGAGACAGATGATCTTGAGCCAGATGGTACACACTATTTAGAGCAGATCGAT
TCGGTAGAGTTTAAGGATTATTCCTTCAGTTATCCTGGTGCTGAGCGAAAGAGCCTATCAGGCATTGATTGGACTATCCAGCGAGGACAG
ACGGTTGGAATTGTTGGTCGTACCGGTGCAGGAAAGACTACCCTGGTTCGACAATTCTTGCGGCAATACCCAGTTGGTGAGGGAGAATTC
TTGGTCAACCAGCAACCGATCGTGGACTACAACCGACACTCGATTGAAGAAAAAATTGGTTATGTTTCCCAAGAACATATTTTATTTTCT
AAGTCTATCCGTGAGAATATAGCGCTTGGTAAAAAAGGAGCCAGCCAAGAAGACTTGATGGAAGCAGTAGCCCAAGCTGCTTTTGCGGAT
GATCTCGAGCGGATGTCTCATGGAATGGACACCCTGATCGGTGAGAAAGGGGTCTCTGTATCAGGAGGTCAAAAACAGCGGATCTCTTTG
GCGCGTGCCTTCTTAAGAGATGCAGATCTCTTGTTGTTAGATGATTCCCTTTCGGCAGTGGATGCGAAGACCGAACAGGCCATTATTGAC
ACCATTCAAAAAGAACGAAAAGACAAGACGACCATCATTGTTTCTCATCGCTTGTCGGCTGTCCATCAGGCTGATTGGATCATCGTCTTG
GATCAAGGACAGATTGTTGAAGAAGGCAGGGCTAGTGATTTATTAGCTCAAGAGGGCTGGTATTATGAACAATACCAACGGCAACAAAAA
CAGGAAGGAGAATAA