tetB(46)

Accession ARO:3004033
DefinitiontetB(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classpleuromutilin antibiotic, nitroimidazole antibiotic, peptide antibiotic, tetracycline antibiotic, cephalosporin, macrolide antibiotic, rifamycin antibiotic, acridine dye, penam, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification20 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Warburton PJ, et al. 2013. J. Antimicrob. Chemother. 68(1):17-22 TetAB46, a predicted heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. (PMID 22941900)

Resistomes

Prevalence of tetB(46) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1180


>gb|AET10445.1|+|tetB(46) [Streptococcus australis]
MKVLKRLLSRITLYPTVFLAGFICLLLATIFSELSPFLLQKMIDGPLTALTHGGGQGDLLQMGGFYLLVLSLGQLISYMGNRILLHGSNQ
VTASLRDQAFQVMQGLPISYFDDKPAGKIATRIVNDTETLRTQFYNSCMILVIYLVRFLFILGILFYLSPMMGLLLCLVFPIFYGIQYLY
KVMTDQPMKDFFDARSEVNTQVNELLHGASMIQLYHQEPGVVEEFEATTQKMLGANDRILLADSIASWTLTELLKFLVIAGILTIAGISF
LQGNIGVTAGFLFININYVINLFDLMANLSRQFPNIRRSLETGSRVLAFLDQPLEADGALELKIEKAEVVFDDVQFAYEEGKPVLKDISI
QAHPGQTLALVGHTGSGKSSIMNLLYRFYDPQEGEIRIDGQNIRHFSRESLRSHMGIVLQDPYLFTGTIASNVAMSQEHIDRNAVKDALK
KVGAWPFVERLEKGIDHPVVEKGSAFSSGERQLISFARTLYMNPQILILDEATSHIDTETEEIIQKAMAVLQKGRTTFIIAHRLSTIQDA
DQILVLSEGRIVERGQHADLVAHGGIYAQMQAIQQTVE


>gb|HQ652506.1|+|2100-3836|tetB(46) [Streptococcus australis]
ATGAAAGTATTGAAACGATTATTATCTAGGATCACGCTTTATCCAACTGTCTTTCTTGCTGGCTTCATTTGCCTCTTACTAGCCACCATT
TTTTCTGAATTGTCTCCCTTTCTTCTCCAAAAGATGATCGATGGGCCTTTGACTGCATTGACCCACGGTGGAGGACAAGGGGACTTGCTT
CAGATGGGAGGATTCTATCTCTTGGTCTTGAGCCTGGGGCAGCTGATTAGCTACATGGGCAATCGGATCTTGCTACATGGAAGTAATCAA
GTAACCGCTAGTCTGAGAGACCAAGCCTTTCAAGTCATGCAAGGGCTGCCTATTTCTTATTTTGATGATAAGCCGGCTGGGAAGATCGCG
ACAAGAATTGTCAATGATACGGAGACCTTGAGGACCCAGTTTTATAACTCTTGTATGATTTTAGTCATCTATTTGGTACGCTTTCTCTTT
ATCCTAGGGATTCTCTTTTACCTGAGTCCTATGATGGGCCTTCTCTTGTGTTTGGTCTTTCCGATTTTCTATGGGATCCAGTATCTCTAC
AAGGTCATGACGGACCAGCCTATGAAGGATTTCTTTGATGCGCGAAGCGAGGTCAATACCCAGGTCAATGAACTCTTGCACGGTGCTAGT
ATGATTCAGCTCTATCATCAAGAGCCTGGTGTGGTGGAGGAGTTTGAAGCCACTACCCAGAAGATGTTAGGAGCAAATGATCGAATCCTC
TTAGCCGATTCTATCGCTTCTTGGACCTTGACGGAATTGCTCAAGTTTTTAGTGATTGCAGGCATTTTGACTATCGCTGGGATTTCTTTC
CTACAGGGTAATATCGGTGTGACGGCTGGTTTCTTATTTATCAATATTAACTATGTGATTAATCTATTTGATCTCATGGCCAATCTTAGT
CGTCAATTCCCAAATATTCGGCGATCCTTAGAAACGGGGAGCCGCGTCCTTGCCTTCTTAGACCAACCGTTAGAGGCCGATGGTGCATTG
GAACTGAAGATAGAAAAGGCAGAGGTCGTGTTTGACGACGTTCAATTTGCCTATGAAGAAGGTAAGCCAGTTCTGAAGGATATTTCCATC
CAAGCCCATCCAGGTCAAACCCTTGCCTTGGTTGGCCATACTGGTTCGGGTAAATCCTCCATTATGAACTTGCTCTATCGTTTCTATGAT
CCGCAGGAGGGAGAAATTCGGATCGACGGCCAGAATATTCGCCATTTCTCTAGAGAGAGTCTTCGCTCCCACATGGGCATTGTTCTACAA
GATCCTTATCTATTTACAGGAACCATTGCTAGTAATGTGGCCATGAGTCAGGAACACATTGATCGGAATGCGGTCAAAGATGCCTTGAAA
AAAGTCGGAGCATGGCCCTTTGTAGAGCGTCTTGAAAAGGGAATCGACCATCCAGTTGTAGAAAAAGGATCGGCCTTTTCAAGTGGCGAA
CGCCAGTTGATTTCCTTTGCGAGGACGCTCTATATGAATCCGCAAATTCTGATTTTGGATGAGGCAACCTCTCACATCGATACGGAAACA
GAAGAAATCATCCAGAAAGCTATGGCTGTCCTGCAAAAGGGCCGGACCACCTTTATCATTGCCCATCGCTTGTCGACTATCCAAGATGCG
GATCAGATCTTGGTTCTATCAGAAGGGCGCATTGTCGAACGTGGGCAACATGCAGACTTAGTTGCCCATGGTGGCATCTACGCCCAGATG
CAAGCTATCCAACAGACGGTTGAATAA