| Accession | ARO:3004239 |
| CARD Short Name | NPS-1 |
| Definition | NPS-1 is a plasmid-encoded class D beta-lactamases identified from two Pseudomonas aeruginosa isolates in 1986. |
| AMR Gene Family | NPS beta-lactamase |
| Drug Class | penam, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Achromobacter xylosoxidanswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Pseudomonas stutzeriwgs |
| Resistomes with Sequence Variants | Achromobacter xylosoxidanswgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Pseudomonas stutzeriwgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + class D beta-lactamase + penam [Drug Class] + cephalosporin [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + NPS beta-lactamase [AMR Gene Family] |
| Publications | Livermore DM, et al. 1986. Antimicrob. Agents Chemother. 29(1):99-103 Characterization of NPS-1, a novel plasmid-mediated beta-lactamase, from two Pseudomonas aeruginosa isolates. (PMID 3089139) Pai H and Jacoby GA. 2001. Antimicrob Agents Chemother 45(10): 2947-2948. Sequences of the NPS-1 and TLE-1 beta-lactamase genes. (PMID 11557499) |
Prevalence of NPS-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 0% | 0.76% | 0% |
| Aeromonas caviae | 0% | 2.6% | 5.91% | 0% |
| Aeromonas hydrophila | 0% | 2.6% | 0% | 0% |
| Providencia rettgeri | 0% | 0% | 0.64% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.03% | 0% |
| Pseudomonas stutzeri | 0% | 0% | 0.76% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 450