ADC-181

Accession ARO:3005244
Synonym(s)ADC 181
CARD Short NameADC-181
DefinitionADC ortholog described by Nodari et al. 2020.
AMR Gene FamilyADC beta-lactamase without carbapenemase activity
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+wgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+wgs
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Nodari CS, et al. 2020. Front Microbiol 11:584603 Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates Belonging to Major Endemic Clones in South America. (PMID 33329450)

Resistomes

Prevalence of ADC-181 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0.18%0%0.26%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 725


>gb|AZK35803.1|+|ADC-181 [Acinetobacter baumannii]
MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVS
KLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIG
LFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLGAPAYGVKSTLPDMLSFIHANLTPQKYPT
DIQRAINETHQGFYQVGTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNRFGTYVVFIPKENIGLVML
TNKRIPNEERIKAAYAVLNAIKK


>gb|MK248721.1|+|1-1152|ADC-181 [Acinetobacter baumannii]
ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAA
GAAATTAAAAAACTGGTAGATCAAAATTTTAAACCATTATTAGAAAAATATGATGTACCAGGTATGGCTGTGGGTGTTATTCAAAATAAT
AAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGT
AAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTA
AAAAATACACCGATTGATCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGCAACCTCGCTTTACAATTTCCAGATGAAGTACAA
ACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGC
CTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACAT
AGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCA
CTTGGTGCCCCAGCATACGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTACCCCACAGAAATATCCGACA
GATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAGTTTTCTTAT
CCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCA
GTTAAGATGTACCATAAAACTGGCTCAACCAACCGTTTCGGAACATATGTGGTCTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTA
ACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA