| Accession | ARO:3000255 |
| CARD Short Name | vanF_cluster |
| Definition | Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
| Sub-Term(s) | 7 ontology terms | Show + vanF part_of + vanH gene in vanF cluster part_of + vanR gene in vanF cluster part_of + vanS gene in vanF cluster part_of + vanX gene in vanF cluster part_of + vanY gene in vanF cluster part_of + vanZ gene in vanF cluster part_of |
| Publications | Patel R, et al. 2000. Antimicrob Agents Chemother 44(3): 705-709. The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster. (PMID 10681342) Fraimow H, et al. 2005. Antimicrob Agents Chemother 49(7): 2625-2633. Putative VanRS-like two-component regulatory system associated with the inducible glycopeptide resistance cluster of Paenibacillus popilliae. (PMID 15980329) |
Prevalence of glycopeptide resistance gene cluster VanF among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster VanF
Model Description:
Regulatory: vanR gene in vanF clustervanS gene in vanF cluster
Core: vanFvanH gene in vanF clustervanX gene in vanF cluster
Accessory: vanY gene in vanF clustervanZ gene in vanF cluster