OXA-59

Accession ARO:3001772
CARD Short NameOXA-59
DefinitionOXA-59 is a beta-lactamase found in Burkholderia pseudomallei.
AMR Gene FamilyOXA beta-lactamase, OXA-42-like beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesBurkholderia pseudomalleig+wgs
Resistomes with Sequence VariantsBurkholderia pseudomalleig+wgs
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ OXA-42-like beta-lactamase [AMR Gene Family]
Publications

Keith KE, et al. 2005. Antimicrob Agents Chemother 49(4): 1639-1641. Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomallei. (PMID 15793160)

Resistomes

Prevalence of OXA-59 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Burkholderia pseudomallei24.4%0%56.47%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|CAG15145.1|+|OXA-59 [Burkholderia pseudomallei]
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEA
WKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAV
DMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR


>gb|AJ632249.1|+|1-810|OXA-59 [Burkholderia pseudomallei]
ATGAAATTCCGACACGCGCTGTCGAGCGCATTCGTTTTGCTGGGTTGCATCGCCGCGTCGGCGCATGCGAAGACGATCTGCACGGCGATC
GCCGATGCGGGCACGGGCAAGCTGCTGGTGCAGGACGGCGATTGCGGCCGCCGCGCATCGCCCGCGTCGACGTTCAAGATCGCGATCAGC
CTGATGGGCTACGACGCAGGCTTCCTGCGCAACGAGCATGACCCGGTGCTGCCGTATCGCGACAGTTACATCGCGTGGGGTGGCGAAGCA
TGGAAGCAGCCGACCGATCCGACGCGCTGGCTCAAGTATTCGGTCGTGTGGTATTCGCAGCAGGTGGCGCACCATCTCGGCGCGCAGCGC
TTCGCGCAGTATGCGAAGGCGTTCGGCTACGGCAATGCGGACGTGTCCGGCGATCCCGGCCAGAACAACGGCCTCGATCGCGCGTGGATC
GGCTCGTCGCTGCAGATCTCGCCGCTCGAACAATTGGAATTCCTCGGCAAGATGCTCAATCGCAAGCTGCCCGTGTCGCCCACAGCCGTC
GACATGACGGAGCGGATCGTCGAATCGACGACGCTTGCCGACGGAACGGTGGTGCACGGCAAGACCGGCGTGTCCTATCCGCTGCTGGCC
GACGGCACACGCGACTGGGCGCGTGGATCCGGCTGGTTCGTCGGCTGGATCGTGCGTGGCAAGCAGACGCTGGTGTTCGCGCGCCTCACG
CAGGACGAGCGCAAGCAGCCCGTTTCAGCCGGCATACGGACGCGCGAGGCCTTCCTGCGCGACTTGCCCCGGCTTCTCGCCGCGCGCTGA