PER-1

Accession ARO:3002363
CARD Short NamePER-1
DefinitionPER-1 is a beta-lactamase found in Pseudomonas aeruginosa.
AMR Gene FamilyPER beta-lactamase
Drug Classpenem, penam, cephalosporin, carbapenem, monobactam
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+p+wgs, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter lwoffiip, Acinetobacter nosocomialiswgs, Acinetobacter pittiip+wgs, Acinetobacter towneriwgs, Acinetobacter wuhouensisp, Klebsiella pneumoniaep+wgs, Proteus mirabilisg+wgs, Proteus vulgariswgs, Providencia rettgerig+wgs, Providencia stuartiig+p, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidawgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter lwoffiip, Acinetobacter nosocomialiswgs, Acinetobacter pittiip+wgs, Acinetobacter towneriwgs, Acinetobacter wuhouensisp, Aeromonas caviaewgs, Klebsiella pneumoniaep+wgs, Proteus mirabilisg+wgs, Proteus vulgariswgs, Providencia rettgerig+wgs, Providencia stuartiig+p, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidawgs
Classification17 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ PER beta-lactamase [AMR Gene Family]
Publications

Nordmann P and Naas T. 1994. Antimicrob Agents Chemother 38(1): 104-114. Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases. (PMID 8141562)

Resistomes

Prevalence of PER-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii2.65%0.05%1.02%0%
Acinetobacter haemolyticus0%2.44%0%0%
Acinetobacter johnsonii0%1.39%3.64%0%
Acinetobacter lwoffii0%1.39%0%0%
Acinetobacter nosocomialis0%0%1.15%0%
Acinetobacter pittii0%0.49%1.7%0%
Acinetobacter towneri0%0%3.85%0%
Acinetobacter wuhouensis0%4.55%0%0%
Aeromonas caviae0%0%0.54%0%
Escherichia coli0%0%0%0%
Klebsiella pneumoniae0%0.01%0.01%0%
Proteus mirabilis0.92%0%0.17%0%
Proteus vulgaris0%0%11.11%0%
Providencia rettgeri8.82%0%0.64%0%
Providencia stuartii6.25%6.82%0%0%
Pseudomonas aeruginosa0.61%0.88%0.33%0%
Pseudomonas putida0%0%0.53%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|CAA79968.1|-|PER-1 [Pseudomonas aeruginosa]
MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKL
DLNQTVIVNRAKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHSDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQV
QYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKTAATNDLGIILLPDGRPLLVA
VFVKDSAESSRTNEAIIAQVAQTAYQFELKKLSALSPN


>gb|Z21957.1|-|285-1211|PER-1 [Pseudomonas aeruginosa]
ATGAATGTCATTATAAAAGCTGTAGTTACTGCCTCGACGCTACTGATGGTATCTTTTAGTTCATTCGAAACCTCAGCGCAATCCCCACTG
TTAAAAGAGCAAATTGAATCCATAGTCATTGGAAAAAAAGCCACTGTAGGCGTTGCAGTGTGGGGGCCTGACGATCTGGAACCTTTACTG
ATTAATCCTTTTGAAAAATTCCCAATGCAAAGTGTATTTAAATTGCATTTAGCTATGTTGGTACTGCATCAGGTTGATCAGGGAAAGTTG
GATTTAAATCAGACCGTTATCGTAAACAGGGCTAAGGTTTTACAGAATACCTGGGCTCCGATAATGAAAGCGTATCAGGGAGACGAGTTT
AGTGTTCCAGTGCAGCAACTGCTGCAATACTCGGTCTCGCACAGCGATAACGTGGCCTGTGATTTGTTATTTGAACTGGTTGGTGGACCA
GCTGCTTTGCATGACTATATCCAGTCTATGGGTATAAAGGAGACCGCTGTGGTCGCAAATGAAGCGCAGATGCACGCCGATGATCAGGTG
CAGTATCAAAACTGGACCTCGATGAAAGGTGCTGCAGAGATCCTGAAAAAGTTTGAGCAAAAAACACAGCTGTCTGAAACCTCGCAGGCT
TTGTTATGGAAGTGGATGGTCGAAACCACCACAGGACCAGAGCGGTTAAAAGGTTTGTTACCAGCTGGTACTGTGGTCGCACATAAAACT
GGTACTTCGGGTATCAAAGCCGGAAAAACTGCGGCCACTAATGATTTAGGTATCATTCTGTTGCCTGATGGACGGCCCTTGCTGGTTGCT
GTTTTTGTGAAAGACTCAGCCGAGTCAAGCCGAACCAATGAAGCTATCATTGCGCAGGTTGCTCAGACTGCGTATCAATTTGAATTGAAA
AAGCTTTCTGCCCTAAGCCCAAATTAA