PER-3

Accession ARO:3002365
CARD Short NamePER-3
DefinitionPER-3 is a beta-lactamase found in Aeromonas spp.
AMR Gene FamilyPER beta-lactamase
Drug Classcarbapenem, cephalosporin, monobactam, penem, penam
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAeromonas caviaeg+p+wgs, Aeromonas hydrophilag+wgs, Pseudomonas aeruginosag+wgs, Vibrio choleraewgs
Resistomes with Sequence VariantsAeromonas caviaeg+p+wgs, Aeromonas hydrophilag+wgs, Pseudomonas aeruginosag+wgs, Vibrio choleraewgs
Classification17 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ PER beta-lactamase [AMR Gene Family]
Publications

Wu CJ, et al. 2011. Antimicrob Agents Chemother 55(12): 5813-5818. Bacteremia due to extended-spectrum-beta-lactamase-producing Aeromonas spp. at a medical center in Southern Taiwan. (PMID 21968366)

Resistomes

Prevalence of PER-3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Aeromonas caviae4.55%1.3%3.76%0%
Aeromonas hydrophila1.54%0%0.81%0%
Pseudomonas aeruginosa0.15%0%0.01%0%
Vibrio cholerae0%0%0.13%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AAU89132.1|+|PER-3 [Aeromonas caviae]
MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKL
DLNQTVIVNRAKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSLSDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQV
QYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKTAATNDLGIILLPDGRPLLVA
VFVKDSAESSRTNEAIIAQVAQTAYQFELKKLSALSPN


>gb|AY740681.1|+|7103-8029|PER-3 [Aeromonas caviae]
ATGAATGTCATTATAAAAGCTGTAGTTACTGCCTCGACGCTACTGATGGTATCTTTTAGTTCATTCGAAACCTCAGCGCAATCCCCACTG
TTAAAAGAGCAAATTGAATCCATAGTCATTGGAAAAAAAGCCACTGTAGGCGTTGCAGTGTGGGGGCCTGACGATCTGGAACCTTTACTG
ATTAATCCTTTTGAAAAATTCCCAATGCAAAGTGTATTTAAATTGCATTTAGCTATGTTGGTACTGCATCAGGTTGATCAGGGAAAGTTG
GATTTAAATCAGACCGTTATCGTAAACAGGGCTAAGGTTTTACAGAATACCTGGGCTCCGATAATGAAAGCGTATCAGGGAGACGAGTTT
AGTGTTCCAGTGCAGCAACTGCTGCAATACTCGGTCTCGCTCAGCGATAACGTGGCCTGTGATTTGTTATTTGAACTGGTTGGTGGACCA
GCTGCTTTGCATGACTATATCCAGTCTATGGGTATAAAGGAGACCGCTGTGGTCGCAAATGAAGCGCAGATGCACGCCGATGATCAGGTG
CAGTATCAAAACTGGACCTCGATGAAAGGTGCTGCAGAGATCCTGAAAAAGTTTGAGCAAAAAACACAGCTGTCTGAAACCTCGCAGGCT
TTGTTATGGAAGTGGATGGTCGAAACCACCACAGGACCAGAGCGGTTAAAAGGTTTGTTACCAGCTGGTACTGTGGTCGCACATAAAACT
GGTACTTCGGGTATCAAAGCCGGAAAAACTGCGGCCACTAATGATTTAGGTATCATTCTGTTGCCTGATGGACGGCCCTTGCTGGTTGCT
GTTTTTGTGAAAGACTCAGCCGAGTCAAGCCGAACCAATGAAGCTATCATTGCGCAGGTTGCTCAGACTGCGTATCAATTTGAATTGAAA
AAGCTTTCTGCCCTAAGCCCAAATTAA