LRA-13

Accession ARO:3002484
CARD Short NameLRA-13
DefinitionLRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska.
AMR Gene Familyclass C LRA beta-lactamase, class D LRA beta-lactamase
Drug Classpenicillin beta-lactam, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ class C LRA beta-lactamase [AMR Gene Family]
+ class D LRA beta-lactamase [AMR Gene Family]
Publications

Allen HK, et al. 2009. ISME J 3(2): 243-251. Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil. (PMID 18843302)

Resistomes

Prevalence of LRA-13 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1200


>gb|ACH58991.1|-|LRA-13 [uncultured bacterium BLR13]
MNFRHIVMAALCGLAWTPAIHATEVCIAIAEAGTGAVLVQRGDCQRQVTPASTFKIAISLMGYDSGFLKDAHAPKLPFRPGYVDWRPSWR
EPTDPAKWMSDSVVWYSQQVTKSLGMQRFADYTRNFKYGNADVSGDAENDGLSMSWISSSLRISPLEQLAFLDKIVNRRLGVSAHAYDMT
AQLTKFDQPPAGWRINGKTGAASGYGWYVGWASKGSRTFVFAHLMQRDATQPQDVSAGVLARDEFLKELPGLMIKDMVDRAVQPLMKKYD
IPGMAVAVTDNGKNYFFNYGLASRETGQAVTSHTLFEIGSLSKTMAATLTSYAQVNGQLALTDTVSRHMPKLRGGGFDKISLLNLGTHTA
GDFPMQVPDHIETYEQLMEYYKNWKPGVAAGGARTYSNLTVGLLGIITAQSMGMPFAEAMENRLFPQLGMHHSYINVPAAEMKNYAQGYN
QANAPVRINPAVLATEAYGVKTDAADLIRFVDANMGLVKLDEKLQRAVTGTHTAYFKTGELTQDLIWEQYPAASKLDRMLAGVSEKMVFE
SNPATRLAPPMPPQADVLINKTGSTGGFGAYALFNPGKKTGIVMLANKSYPGAERVTAAWHILDQLDQR


>gb|EU408352.1|-|35395-37224|LRA-13 [uncultured bacterium BLR13]
ATGAATTTTCGCCACATAGTCATGGCGGCGCTGTGCGGTCTCGCCTGGACGCCAGCCATCCACGCCACCGAAGTGTGTATCGCCATCGCC
GAGGCCGGCACCGGCGCTGTGCTGGTCCAGCGCGGCGATTGCCAGCGCCAGGTGACGCCGGCGTCGACCTTCAAGATCGCCATCAGCCTG
ATGGGCTACGACTCGGGTTTTCTGAAGGACGCGCACGCGCCGAAACTGCCGTTCCGTCCAGGCTATGTCGATTGGCGGCCCAGCTGGCGC
GAACCGACGGATCCGGCCAAGTGGATGAGCGATTCGGTCGTATGGTATTCGCAGCAGGTGACAAAATCCCTGGGCATGCAGCGTTTCGCC
GACTACACGCGGAACTTCAAGTATGGCAATGCCGACGTTTCGGGGGACGCGGAAAATGACGGCCTGAGCATGTCGTGGATAAGTTCCTCG
CTGCGGATCTCGCCGCTGGAACAACTCGCGTTCCTGGACAAGATCGTCAACCGTCGGCTGGGCGTGAGCGCCCATGCCTACGACATGACC
GCGCAATTGACGAAATTCGATCAGCCTCCGGCGGGATGGCGCATCAACGGCAAGACCGGCGCCGCCTCCGGTTATGGCTGGTACGTGGGA
TGGGCGTCGAAAGGTTCGCGAACCTTCGTCTTTGCGCACCTGATGCAGAGGGACGCGACGCAGCCGCAAGACGTGTCGGCGGGCGTGCTG
GCGCGTGACGAATTCCTCAAGGAACTCCCCGGCTTGATGATCAAGGATATGGTGGACCGCGCCGTCCAGCCGTTGATGAAGAAATACGAT
ATCCCGGGGATGGCGGTGGCCGTCACCGACAACGGCAAGAACTACTTCTTCAACTACGGGCTGGCGTCGAGGGAAACCGGGCAAGCCGTT
ACCAGCCACACCCTGTTCGAGATCGGTTCGCTGAGCAAGACCATGGCGGCAACGCTGACTTCCTACGCGCAGGTCAACGGCCAGCTTGCG
TTGACCGACACGGTCAGCCGGCATATGCCCAAGCTGCGCGGCGGCGGCTTCGACAAGATCAGCCTGCTCAATCTGGGCACCCACACGGCC
GGCGATTTTCCGATGCAGGTTCCCGACCATATCGAGACCTACGAGCAGCTGATGGAGTACTACAAAAACTGGAAGCCCGGGGTTGCTGCG
GGCGGCGCCAGGACCTACTCCAACCTGACCGTCGGCCTGCTGGGCATCATCACGGCGCAAAGCATGGGCATGCCGTTTGCGGAGGCGATG
GAAAACAGGTTGTTCCCCCAGCTTGGCATGCATCACAGCTATATCAATGTGCCGGCGGCGGAGATGAAGAACTACGCGCAAGGCTACAAC
CAGGCCAACGCACCGGTCAGGATCAATCCGGCGGTGCTGGCAACCGAGGCATACGGGGTAAAGACCGATGCCGCCGACTTGATCCGGTTT
GTCGACGCCAACATGGGGTTGGTCAAGCTGGACGAAAAACTGCAGCGCGCGGTCACCGGCACGCACACCGCCTACTTCAAGACGGGTGAG
CTGACGCAGGATCTGATCTGGGAACAATATCCCGCCGCATCGAAACTCGATCGCATGCTGGCGGGCGTTTCCGAAAAAATGGTCTTTGAA
AGCAATCCCGCGACCAGGCTGGCGCCGCCGATGCCGCCGCAAGCGGATGTGCTGATCAACAAGACCGGATCAACCGGCGGCTTTGGCGCC
TATGCGCTGTTCAACCCGGGCAAGAAGACCGGCATCGTGATGCTGGCGAACAAGAGCTATCCTGGCGCAGAAAGGGTGACGGCGGCCTGG
CACATACTGGATCAACTGGACCAGCGTTAG

Curator Acknowledgements
Curator Description Most Recent Edit