lmrB

Accession ARO:3002813
CARD Short NamelmrB
DefinitionlmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classnucleoside antibiotic, lincosamide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesBacillus subtilisg+wgs
Resistomes with Sequence VariantsBacillus subtilisg+wgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Yoshida K, et al. 2004. J Bacteriol 186(17): 5640-5648. Bacillus subtilis LmrA is a repressor of the lmrAB and yxaGH operons: identification of its binding site and functional analysis of lmrB and yxaGH. (PMID 15317768)

Resistomes

Prevalence of lmrB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacillus subtilis38.71%0%3.47%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 900


>gb|KIX81495.1|-|lmrB [Bacillus subtilis]
METTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFS
ILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWISLPFLV
LALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGIVFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPM
FILGVIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKYGPKWLVIPGFVIVTVVLWFFSNVTTTST
AVLIIILHTCLMIGISMIMMPAQTNGLNQLPREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAGVQ
HAFVFAMIVAIIGLIGAFFMKRVKVDH


>gb|JYFL01000006.1|-|112070-113503|lmrB [Bacillus subtilis]
TTGGAAACAACAGCTAAAGCATCTCAGCAATACAAAGTGATGCCGATTATGATTTCCTTGCTGTTGGCCGGTTTTATCGGCATGTTCAGT
GAAACAGCGCTGAATATTGCGTTAACCGACCTTATGAAGGAATTGAACATTACAGCGGCAACCGTCCAATGGTTAACGACGGGCTACCTG
CTTGTACTCGGTATCCTTGTTCCTGTTTCAGGACTGCTGTTGCAGTGGTTCACAACAAGACAGCTTTTTACCGTGTCACTTATCTTTTCA
ATTTTAGGTACATTCATTGCGGCGCTTGCGCCGAGCTTCTCGTTTTTATTAGCGGCAAGGATCGTTCAGGCACTTGGAACCGGTCTTTTA
CTGCCGCTGATGTTTAACACAATCTTGGTGATTTTCCCGCCTCATAAACGGGGTGCCGCAATGGGAACGATCGGGCTTGTCATTATGTTC
GCGCCCGCCATCGGCCCAACTTTCTCAGGATTGGTTCTGGAGCATCTCAACTGGCACTGGATTTTCTGGATCTCTCTTCCATTCCTTGTG
CTGGCGCTTGTTTTCGGTATCGCATATATGCAAAATGTATCTGAAACGACAAAGCCGAAAATCGATGTATTGTCTATCATCCTGTCGACG
ATTGGCTTCGGCGGCATTGTATTCGGATTCAGCAACGCGGGTGAAGGCTCCGGGGGATGGTCCAGCCCGACTGTTATCGTGTCGCTGATT
GTCGGCGTTGTCGGCCTTATCTTATTTTCAATCCGCCAGCTGACAATGAAGCAGCCTATGATGAACCTCCGTGCGTTCAAATACCCGATG
TTTATTTTGGGTGTGATCATGGTGTTCATTTGTATGATGGTCATTCTGTCATCTATGCTGCTTCTGCCGATGTATCTGCAAGGCGGCTTA
GTCCTCACTGCATTTGCATCTGGTCTTGTTCTCTTGCCGGGCGGTATTTTAAATGGATTTATGTCCCCTGTTACAGGCCGCTTGTTCGAT
AAATACGGGCCGAAATGGCTTGTCATTCCGGGATTTGTGATTGTCACCGTTGTACTATGGTTCTTCTCAAATGTCACGACCACTTCAACA
GCTGTGCTGATTATCATCCTGCACACCTGCTTGATGATCGGGATTTCTATGATCATGATGCCTGCACAGACAAACGGTTTAAACCAACTG
CCGCGTGAATTTTATCCAGACGGCACCGCCATTATGAACACGCTGCAGCAAATGGCCGGCGCTATCGGAACAGCGGTTGCGGTCAGCATT
ATGGCTGCAGGCCAGCATGATTATATGAGTACAGTTAAAAACCCTGCCGATCCGGCAGTCATCCCGCAAGCTTTGACAGCAGGCGTACAG
CACGCATTTGTGTTTGCAATGATTGTTGCCATTATCGGTTTAATTGGCGCTTTCTTTATGAAACGCGTTAAAGTAGATCATTAA