smeA

Accession ARO:3003051
CARD Short NamesmeA
DefinitionsmeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpenam, cephamycin, cephalosporin, aminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Li XZ, et al. 2002. Antimicrob Agents Chemother 46(2): 333-343. SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. (PMID 11796339)

Resistomes

Prevalence of smeA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 750


>gb|AAD51344.1|+|smeA [Stenotrophomonas maltophilia]
MSLLRPLSRSPRPLLLPLLLALAACSADRTDAPAMPEVGVIIASAQPLALQQTLPGRAVPFEISEVRPQIGGLIRQRLFTEGQQVKAGQL
LYQVDPAPYQAAFDTARGQLAQAEATVLSAQPKAERTRALVSMDAASKQDADDATSALKQAQANVIAARAALQAARINLDYTRVTAPIDG
RIGTSSVTAGALVAAGQDTALTTIQRLDPVYLDVTQSSTQMLALRKRLDAGLVKAIDGKAQVKVLLEDGSTYAHEGTLEFVGSAVDPGTG
NVKLRAVIPNPDGLLLPGMYLKAVLPMATDARALLVPQKAVVRNERGEPLLRLLDAKDHVVERRVSTGQVVGNQWQITSGLKAGERVIVS
NGSAVSLGQQVKAVAPTTAQLAAMPAVDPNGNTDEKSH


>gb|AF173226.1|+|2559-3755|smeA [Stenotrophomonas maltophilia]
ATGTCTCTCCTGCGCCCGCTGTCCCGTTCCCCGCGTCCCCTGCTGTTGCCCCTGCTGCTGGCCCTGGCGGCCTGTTCGGCGGACAGGACC
GACGCCCCGGCCATGCCCGAAGTGGGCGTCATCATCGCCAGCGCGCAGCCGCTGGCACTCCAGCAGACCTTGCCCGGCCGTGCCGTGCCG
TTCGAGATCTCCGAGGTGCGGCCGCAGATCGGCGGCCTGATCCGCCAGCGGTTGTTCACCGAAGGCCAGCAGGTCAAGGCAGGGCAGCTG
CTGTACCAGGTCGACCCGGCACCGTACCAGGCGGCCTTCGATACCGCCCGCGGGCAGCTGGCGCAGGCCGAGGCCACCGTGTTGTCGGCA
CAGCCGAAGGCCGAGCGTACCCGCGCGCTGGTGAGCATGGATGCAGCCAGCAAGCAGGACGCCGACGATGCCACCTCGGCGTTGAAGCAG
GCGCAGGCCAACGTGATTGCCGCGCGCGCTGCATTGCAGGCTGCCCGCATCAACCTCGACTACACCCGGGTGACCGCCCCCATCGACGGT
CGCATCGGCACCTCCAGCGTCACCGCCGGCGCGCTGGTCGCGGCCGGCCAGGATACGGCGTTGACCACCATCCAGCGGCTGGACCCGGTG
TACCTGGATGTCACCCAGTCCAGCACGCAGATGCTGGCGCTGCGCAAGCGGCTCGATGCGGGCCTAGTGAAGGCCATCGATGGCAAGGCA
CAGGTTAAGGTGCTGCTGGAGGACGGCAGCACCTACGCGCATGAAGGCACGTTGGAGTTCGTCGGCAGCGCAGTGGATCCGGGCACCGGA
AACGTGAAGCTGCGCGCGGTCATTCCGAACCCGGACGGCCTGCTGTTGCCGGGCATGTACCTGAAGGCGGTGCTGCCGATGGCCACCGAC
GCGCGTGCCCTGCTGGTGCCGCAGAAGGCAGTGGTGCGCAACGAACGCGGCGAACCGCTGCTGCGCCTGCTCGACGCCAAGGATCATGTG
GTCGAGCGCCGCGTCAGCACCGGCCAGGTGGTCGGTAACCAGTGGCAGATCACCAGCGGCCTCAAGGCTGGCGAACGGGTGATCGTCAGC
AACGGCAGCGCGGTATCGCTCGGTCAGCAGGTGAAAGCGGTGGCGCCCACGACGGCGCAGTTGGCGGCGATGCCGGCGGTCGATCCGAAC
GGCAACACCGACGAAAAGTCGCACTGA