smeA

Accession ARO:3003051
DefinitionsmeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpenam, cephalosporin, aminoglycoside antibiotic, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Li XZ, et al. 2002. Antimicrob Agents Chemother 46(2): 333-343. SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. (PMID 11796339)

Resistomes

Prevalence of smeA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Klebsiella pneumoniae0%0%0%
Stenotrophomonas maltophilia58.33%0%51.32%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 750


>gb|AAD51344.1|+|smeA [Stenotrophomonas maltophilia]
MSLLRPLSRSPRPLLLPLLLALAACSADRTDAPAMPEVGVIIASAQPLALQQTLPGRAVPFEISEVRPQIGGLIRQRLFTEGQQVKAGQL
LYQVDPAPYQAAFDTARGQLAQAEATVLSAQPKAERTRALVSMDAASKQDADDATSALKQAQANVIAARAALQAARINLDYTRVTAPIDG
RIGTSSVTAGALVAAGQDTALTTIQRLDPVYLDVTQSSTQMLALRKRLDAGLVKAIDGKAQVKVLLEDGSTYAHEGTLEFVGSAVDPGTG
NVKLRAVIPNPDGLLLPGMYLKAVLPMATDARALLVPQKAVVRNERGEPLLRLLDAKDHVVERRVSTGQVVGNQWQITSGLKAGERVIVS
NGSAVSLGQQVKAVAPTTAQLAAMPAVDPNGNTDEKSH


>gb|AF173226|+|2559-3755|smeA [Stenotrophomonas maltophilia]
ATGTCTCTCCTGCGCCCGCTGTCCCGTTCCCCGCGTCCCCTGCTGTTGCCCCTGCTGCTGGCCCTGGCGGCCTGTTCGGCGGACAGGACC
GACGCCCCGGCCATGCCCGAAGTGGGCGTCATCATCGCCAGCGCGCAGCCGCTGGCACTCCAGCAGACCTTGCCCGGCCGTGCCGTGCCG
TTCGAGATCTCCGAGGTGCGGCCGCAGATCGGCGGCCTGATCCGCCAGCGGTTGTTCACCGAAGGCCAGCAGGTCAAGGCAGGGCAGCTG
CTGTACCAGGTCGACCCGGCACCGTACCAGGCGGCCTTCGATACCGCCCGCGGGCAGCTGGCGCAGGCCGAGGCCACCGTGTTGTCGGCA
CAGCCGAAGGCCGAGCGTACCCGCGCGCTGGTGAGCATGGATGCAGCCAGCAAGCAGGACGCCGACGATGCCACCTCGGCGTTGAAGCAG
GCGCAGGCCAACGTGATTGCCGCGCGCGCTGCATTGCAGGCTGCCCGCATCAACCTCGACTACACCCGGGTGACCGCCCCCATCGACGGT
CGCATCGGCACCTCCAGCGTCACCGCCGGCGCGCTGGTCGCGGCCGGCCAGGATACGGCGTTGACCACCATCCAGCGGCTGGACCCGGTG
TACCTGGATGTCACCCAGTCCAGCACGCAGATGCTGGCGCTGCGCAAGCGGCTCGATGCGGGCCTAGTGAAGGCCATCGATGGCAAGGCA
CAGGTTAAGGTGCTGCTGGAGGACGGCAGCACCTACGCGCATGAAGGCACGTTGGAGTTCGTCGGCAGCGCAGTGGATCCGGGCACCGGA
AACGTGAAGCTGCGCGCGGTCATTCCGAACCCGGACGGCCTGCTGTTGCCGGGCATGTACCTGAAGGCGGTGCTGCCGATGGCCACCGAC
GCGCGTGCCCTGCTGGTGCCGCAGAAGGCAGTGGTGCGCAACGAACGCGGCGAACCGCTGCTGCGCCTGCTCGACGCCAAGGATCATGTG
GTCGAGCGCCGCGTCAGCACCGGCCAGGTGGTCGGTAACCAGTGGCAGATCACCAGCGGCCTCAAGGCTGGCGAACGGGTGATCGTCAGC
AACGGCAGCGCGGTATCGCTCGGTCAGCAGGTGAAAGCGGTGGCGCCCACGACGGCGCAGTTGGCGGCGATGCCGGCGGTCGATCCGAAC
GGCAACACCGACGAAAAGTCGCACTGA