smeB

Accession ARO:3003052
DefinitionsmeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, acridine dye, penam, aminoglycoside antibiotic, antibacterial free fatty acids, macrolide antibiotic, aminocoumarin antibiotic, glycylcycline, fluoroquinolone antibiotic, triclosan, monobactam, diaminopyrimidine antibiotic, carbapenem, phenicol antibiotic, cephalosporin, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification26 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Li XZ, et al. 2002. Antimicrob Agents Chemother 46(2): 333-343. SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. (PMID 11796339)

Resistomes

Prevalence of smeB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Klebsiella pneumoniae0%0%0%
Stenotrophomonas maltophilia87.5%0%83.55%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 2090


>gb|AAD51345.1|+|smeB [Stenotrophomonas maltophilia]
MVRFFIDRPIFAWVIAIAVSLLGLLAILILPVDRYPQIAPPTITIRATYTGASSQTVENAVTQVIEQSQQSLDHLMYMTSTSASDGSAQV
NLVFATGTNPDTAQVQVQNQLQAAMATLPQAVQQNGLTITKSSGSIFEVLSFTSEDGSMDNFDVANFMEARIDDQISRVSGVGNIQPIGQ
EYAMRIWLDPEKMRQYALMPWDIETALQAQNTDVSAGELGGQPALKGQQLDATVTARSRLHTPEQFAQVVLKADANGSVVRLGDVAKIGL
GPESYDSISTFNGKPSASLGIELNAGANAIAVSKAIDARLQQLQKYWPHGYTAHVAFTTTPFVTISLKEVVITLIEAIILVVLVMYLFLQ
NWRATLIPTIAVPVVLLGTFGVLAAFGYSINTLTMFALVLAIGLLVDDAIVVVENVERVMTFEGLAPKPATLKAMGQITGALVGIVLVLT
AVFLPMAFFSGVTGVIYRQFSVTIAAAMILSVLVAMTITPALCGSILHQIPKGGHPHGDHGGEPSLLGKFFIWFNHRFERTSNGLRHRVD
RFLGRRTLGVLFYLVLSVATGLLLWHLPGAFLPDEDQGMLNALVKLPAGSTLEQTRAVMDRLSAVAVKDDGVLSIQATAGFSVTGSGQNV
GQAFIRLKDWDDRKDDADTIAARLTRAMASVPDAQVFITSPPAILGLGDAGGFTLELQDEGGAGHAAAVAARNTLLKEAAKDPKLVNVRY
ASLEDAPVYAVKVDDAKAQAMGVNPQDVNDTLNAALGGDFVNNFIYKGRIKKVFIQGTAEARMQPQDIERWSVRNQAGQMVPLSSLISTH
WTSAPAAVQRYNGISAMEITGQPAPGVSSGEAMAEIARLADTLPEGFSHAWSDMAYQEQLSGNQAPMLYAISLLFVFLCLAALYESWAVP
FAVMLAVPVGMFGAVLMMNLRGLNNDVYFQVGLLTTIGLAAKNGILIVEFARILEQQGKSTREAILQAVYLRLRPIVMTSLAFLMGVLPL
VFATGAGSAARRSLGTGVAGGTVASMVLGMFFVPLFYLLVRRLFPGRAPADATVPETSP


>gb|AF173226|+|3768-6917|smeB [Stenotrophomonas maltophilia]
ATGGTTCGTTTCTTCATCGACCGGCCGATCTTCGCCTGGGTGATCGCCATCGCGGTCAGCCTGCTCGGCCTGCTCGCGATCCTGATCCTG
CCGGTGGACCGCTACCCGCAGATCGCCCCGCCCACCATCACCATCCGCGCCACCTACACCGGCGCCTCGTCGCAGACCGTGGAAAACGCG
GTCACCCAGGTCATCGAGCAGTCCCAGCAAAGCCTCGATCACCTGATGTACATGACCTCGACCAGTGCCTCCGACGGCTCGGCGCAGGTC
AACCTGGTGTTCGCCACCGGTACCAATCCGGATACCGCGCAGGTGCAGGTGCAGAACCAGCTGCAGGCCGCCATGGCCACGCTGCCGCAG
GCGGTGCAGCAGAACGGCCTGACCATCACCAAGTCCAGTGGTTCGATCTTCGAGGTGCTGTCGTTCACCAGCGAAGACGGCAGCATGGAC
AACTTCGATGTCGCCAACTTCATGGAAGCGCGCATCGATGACCAGATCAGCCGCGTCAGCGGTGTCGGCAACATCCAGCCGATCGGCCAG
GAATACGCCATGCGCATCTGGCTGGATCCGGAGAAGATGCGCCAGTACGCGCTGATGCCCTGGGACATCGAGACCGCATTGCAGGCACAG
AACACCGATGTCTCCGCCGGTGAGCTGGGTGGCCAGCCGGCGCTGAAGGGCCAGCAGCTCGACGCCACGGTAACCGCGCGCAGCCGCCTG
CACACGCCCGAGCAGTTCGCGCAGGTGGTGCTCAAGGCCGATGCCAACGGCAGCGTGGTGCGTCTGGGCGACGTGGCAAAGATCGGCCTC
GGGCCGGAAAGCTACGACAGCATCAGCACCTTCAATGGCAAGCCGTCGGCGTCGCTGGGCATTGAACTCAATGCCGGTGCCAACGCGATC
GCCGTCTCCAAGGCCATCGATGCACGGCTTCAGCAGCTGCAGAAGTACTGGCCGCATGGCTACACCGCCCACGTGGCCTTCACCACCACC
CCATTCGTGACCATTTCGCTGAAGGAAGTGGTGATCACCCTGATCGAAGCGATCATCCTGGTGGTGCTGGTGATGTACCTGTTCCTGCAG
AACTGGCGCGCCACGCTGATCCCGACCATCGCGGTGCCGGTGGTGCTGCTGGGCACGTTCGGCGTGCTGGCTGCATTCGGGTATTCGATC
AACACCCTGACCATGTTCGCACTGGTGCTGGCCATCGGCCTGCTGGTGGACGATGCCATCGTGGTGGTGGAGAACGTAGAGCGGGTGATG
ACCTTCGAAGGGCTGGCGCCGAAGCCGGCCACGCTGAAGGCGATGGGCCAGATCACCGGCGCGCTGGTCGGCATCGTGCTGGTGCTGACC
GCGGTGTTCCTGCCGATGGCGTTCTTCAGCGGTGTAACCGGGGTGATCTATCGCCAGTTCTCGGTGACGATCGCCGCCGCGATGATCCTG
TCGGTGCTGGTGGCGATGACCATCACCCCGGCACTGTGTGGCAGCATCCTGCACCAGATTCCCAAGGGCGGCCATCCGCATGGCGACCAC
GGTGGCGAGCCGAGCCTGCTGGGCAAGTTCTTCATCTGGTTCAACCACCGCTTCGAGCGCACCTCCAACGGCCTGCGCCATCGCGTGGAT
CGTTTCCTCGGCCGCCGCACGCTCGGCGTGCTGTTCTACCTGGTGCTGAGCGTGGCCACCGGCCTGTTGCTGTGGCACCTGCCGGGCGCG
TTCCTGCCCGATGAAGACCAGGGCATGCTCAACGCGCTGGTGAAGCTGCCGGCCGGTTCCACGCTGGAGCAGACGCGGGCGGTGATGGAT
CGTCTGAGTGCCGTCGCGGTGAAGGACGACGGCGTGCTCTCGATCCAGGCCACCGCCGGTTTCAGTGTTACCGGCAGCGGCCAGAACGTC
GGCCAGGCCTTCATCCGGCTGAAGGACTGGGATGACCGCAAGGACGACGCCGATACCATCGCCGCACGCTTGACGCGGGCGATGGCCAGC
GTGCCCGATGCGCAGGTGTTCATCACCTCGCCACCGGCCATCCTGGGCCTCGGCGATGCGGGTGGCTTCACCCTGGAACTGCAGGACGAA
GGCGGTGCAGGCCATGCCGCCGCCGTGGCCGCGCGCAACACGCTGCTGAAGGAAGCCGCCAAGGACCCGAAGCTGGTCAACGTGCGCTAC
GCCAGCCTGGAAGACGCGCCGGTATACGCGGTGAAGGTGGACGACGCCAAGGCGCAGGCGATGGGCGTGAACCCGCAGGACGTCAATGAC
ACCTTGAACGCGGCGTTGGGCGGCGACTTCGTCAACAACTTCATCTACAAGGGGCGCATCAAGAAGGTGTTCATCCAGGGCACCGCCGAA
GCACGCATGCAGCCGCAGGACATCGAGCGCTGGAGCGTGCGCAACCAGGCCGGGCAGATGGTGCCGCTGTCGTCGTTGATCAGCACGCAT
TGGACCAGCGCGCCGGCCGCAGTGCAGCGCTACAACGGCATCTCGGCGATGGAAATCACCGGCCAGCCGGCACCGGGCGTCAGCTCCGGC
GAGGCGATGGCCGAGATCGCGCGCCTGGCCGACACGCTGCCGGAAGGCTTCAGCCATGCCTGGTCGGACATGGCCTACCAGGAACAGCTG
TCGGGCAACCAGGCGCCGATGCTGTACGCCATCTCGCTGCTGTTCGTGTTCCTGTGCCTGGCCGCGCTGTATGAAAGCTGGGCGGTGCCG
TTCGCGGTGATGCTGGCGGTGCCGGTGGGCATGTTCGGCGCCGTGCTGATGATGAACCTGCGTGGCCTCAACAACGACGTGTACTTCCAG
GTCGGCCTGCTGACCACGATTGGTCTGGCAGCGAAGAACGGCATCCTGATCGTCGAGTTCGCGCGCATCCTCGAACAGCAGGGCAAGAGC
ACCCGCGAAGCGATCCTGCAGGCGGTCTACCTGCGGCTGCGGCCGATCGTAATGACCTCGCTGGCGTTCCTGATGGGCGTACTGCCGCTG
GTGTTCGCCACCGGCGCCGGTTCGGCTGCGCGCCGTTCGCTGGGTACCGGCGTGGCCGGTGGTACGGTTGCCTCGATGGTGCTGGGCATG
TTCTTCGTGCCGTTGTTCTACCTGCTGGTGCGCCGCCTGTTCCCGGGCCGCGCGCCGGCCGACGCCACTGTCCCGGAGACAAGCCCATGA