Laribacter hongkongensis ampC beta-lactamase

Accession ARO:3004292
Synonym(s)blaLHK-5
CARD Short NameLhon_ampC_BLA
DefinitionA chromosome-encoded class C beta-lactamase described in the pathogen Laribacter hongkongensis, often associated with gastroenteritis. Laribacter ampC has been shown to confer resistance to non-carbapenem beta-lactamases, as described by Lau et al. 2005.
AMR Gene FamilyampC-type beta-lactamase
Drug Classcephalosporin, penam
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesLaribacter hongkongensisg
Resistomes with Sequence VariantsLaribacter hongkongensisg+wgs
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ ampC-type beta-lactamase [AMR Gene Family]
Publications

Lau SK, et al. 2005. Antimicrob Agents Chemother 49(5): 1957-1964. Cloning and characterization of a chromosomal class C beta-lactamase and its regulatory gene in Laribacter hongkongensis. (PMID 15855519)

Resistomes

Prevalence of Laribacter hongkongensis ampC beta-lactamase among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Laribacter hongkongensis33.33%0%6.25%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AAT46346.1|+|Laribacter hongkongensis ampC beta-lactamase [Laribacter hongkongensis]
MKKRITPFSRFASKGLFACSAGMLLVTVAHAANTAAAPAGMDAMVQTVMQAHQIPGMAIAIIQPGKTTYHNYGVASRETGQPVRETTLFE
IGSLSKPFTALVAQRAETEGRIDLSAPASRYVAALRGSAFDRITLRQLGTYSAGGLPLQFPDNVTTPADVLAYYQHWQPVHPAGTTRLYS
NPSIGLMGLAASQATGESFAGLLGTTVLHPLGMNSTYLQVPPEARSRYAMGYTAAGKAVRVSPGPLDEETYGVKSTTADMAGFLLAHMDP
ARSKGALQSALQQTRVPVYCAGQTRQGLGWESYQDWKNLDVLLAGNSNQMVFEPQPVKACPAGTMNDPDVWVNKTGSTAGFGAYAVFLPA
RQTGIVILANRNFPIADRIRLAHGILTALH


>gb|AY632076.1|+|1-1173|Laribacter hongkongensis ampC beta-lactamase [Laribacter hongkongensis]
ATGAAAAAACGGATTACCCCATTTTCCCGCTTTGCATCAAAAGGCCTTTTCGCCTGTAGCGCAGGCATGTTGCTGGTGACGGTGGCACAT
GCTGCCAATACGGCAGCAGCACCAGCCGGCATGGATGCCATGGTACAAACCGTGATGCAGGCACACCAGATTCCGGGCATGGCCATTGCC
ATCATCCAGCCAGGAAAGACCACTTATCACAATTATGGTGTCGCCTCCCGCGAAACCGGCCAGCCGGTCCGGGAAACCACCCTGTTTGAA
ATCGGGTCCCTTTCCAAACCGTTTACTGCACTGGTCGCCCAGCGGGCTGAAACCGAAGGCCGGATTGACCTGTCTGCACCGGCCAGCCGC
TACGTTGCCGCCCTGCGAGGCAGTGCATTCGACCGGATCACCCTCAGGCAGCTCGGTACTTATAGCGCAGGCGGATTACCGCTCCAGTTT
CCTGACAATGTCACCACCCCGGCAGACGTGCTGGCTTATTACCAGCATTGGCAACCTGTCCATCCGGCAGGTACCACCCGGCTGTATTCC
AATCCGAGCATTGGCCTGATGGGGCTGGCTGCCAGTCAGGCAACCGGAGAGTCCTTTGCCGGCCTGCTCGGGACAACGGTGCTGCACCCC
CTCGGCATGAACTCGACCTATCTGCAAGTGCCCCCGGAGGCCCGTTCACGTTATGCCATGGGATATACCGCCGCCGGAAAAGCGGTCAGG
GTCAGCCCCGGTCCGCTGGATGAGGAAACCTACGGCGTCAAGTCCACAACCGCAGACATGGCCGGATTTTTATTGGCGCATATGGACCCT
GCGCGCAGCAAAGGTGCATTGCAGTCGGCATTACAGCAAACACGTGTACCGGTTTATTGCGCCGGACAGACCCGGCAAGGACTGGGCTGG
GAAAGTTATCAAGACTGGAAAAACCTAGACGTGCTGCTGGCGGGAAATTCAAATCAAATGGTGTTTGAGCCGCAGCCGGTAAAAGCCTGT
CCTGCCGGCACCATGAATGATCCTGATGTGTGGGTCAACAAGACCGGTTCTACTGCGGGATTCGGCGCTTATGCCGTATTCCTGCCTGCC
CGACAGACCGGCATTGTCATCCTGGCCAACCGTAATTTCCCGATTGCAGACCGTATCCGGCTCGCTCACGGGATTTTGACCGCATTGCAC
TGA