PDC-376

Accession ARO:3005302
CARD Short NamePDC-376
DefinitionPDC-376 is a class C beta-lactamase found in Pseudomonas aeruginosa.
AMR Gene FamilyPDC beta-lactamase
Drug Classcephalosporin, carbapenem, monobactam
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ PDC beta-lactamase [AMR Gene Family]
Resistomes

Prevalence of PDC-376 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 800


>gb|WP_148044462.1|+|PDC-376 [Pseudomonas aeruginosa]
MRDTGFPCLCGIAASTLLFAATSAIAGEAPADRLKTLVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGS
VSKTFTATLAGYALAQDKMRLDDRASLHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYTPGSQRLYSNP
SIGLFGYLAARSLGQPFERIMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER
LVKPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGSD
LGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR


>gb|NG_065928.1|+|1-1194|PDC-376 [Pseudomonas aeruginosa]
ATGCGCGATACCGGATTCCCCTGCCTGTGCGGCATCGCCGCCTCCACACTGCTGTTCGCCGCCACCTCGGCCATTGCCGGCGAGGCCCCG
GCGGATCGCCTGAAGACACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGATATTCCGGGCCTGGCCGTGGCCATCAGCCTG
AAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCTTCGAAAGAGGACGGTCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCG
GTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCTGCACTGGCCG
GCGCTGCAAGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCG
GTGCAGAAAGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACACGCCGGGCAGCCAGCGCCTCTACTCCAACCCG
AGCATCGGTCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGATCATGGAGCAGCAACTGTTCCCGGCACTGGGC
CTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGT
CCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGC
CTGGTCAAGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCC
TACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCGGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGACTGCCCGCG
CCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATCCCAGGCAGCGAC
CTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAG
GCCAAGGTGCCGCTGAAGCGCTGA

Curator Acknowledgements
Curator Description Most Recent Edit