SIE-1

Accession ARO:3007846
CARD Short NameSIE-1
DefinitionSIE-1 is SIE beta-lactamase gene family variant.
AMR Gene FamilySIE beta-lactamase
Drug Classcephalosporin, carbapenem
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ SIE beta-lactamase [AMR Gene Family]
Publications

Wilson LA, et al. 2021. Antimicrob Agents Chemother 65(10):e0093621 Kinetic and Structural Characterization of the First B3 Metallo-β-Lactamase with an Active-Site Glutamic Acid. (PMID 34310207)

Resistomes

Prevalence of SIE-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 550


>gb|APL95059.1|-|SIE-1 [Sphingobium indicum B90A]
MIATMTIAASLAISPAAAATGPEPEAMAAMDRAGGARASDDPLTRPMAVERAKEWLAPLPPERVFGNSYLVGFAGLSVALIDTGAGLVLI
DGALPQAAPMILSNVRKLGFDPRDIKFILSTEPHYDHAGGIAALARDTGATVVASRRGAEGLRAGAHAKDDPQFDYGGAWPAVSRLRVMK
DGEVLRIGRASITAHATPGHTMGSMTWSWNACEGKRCKAIVFASSLNPVSADRYRFTAPSSAPIVKGFEASYRRMGALKCDILISAHPDN
AGAGRYGSGSGACRSYAERSRRLLAKRLAEERRETSK


>gb|CP013070.1|-|2379246-2380169|SIE-1 [Sphingobium indicum B90A]
ATGATCGCAACGATGACAATCGCCGCGTCGCTGGCCATCAGCCCGGCGGCGGCAGCGACAGGGCCGGAGCCGGAAGCCATGGCGGCCATG
GACCGGGCGGGCGGCGCCCGCGCCTCCGATGACCCTCTGACCCGGCCGATGGCGGTCGAAAGAGCCAAGGAATGGCTTGCGCCCCTGCCG
CCCGAAAGGGTTTTCGGCAACAGCTATCTGGTCGGCTTCGCGGGTCTCAGCGTCGCCTTGATCGACACGGGTGCGGGCCTGGTGCTGATC
GACGGCGCGCTTCCGCAGGCGGCGCCGATGATCCTCAGCAATGTTCGCAAGCTGGGCTTCGACCCCAGAGACATCAAATTTATTCTGAGT
ACCGAGCCGCATTATGATCATGCTGGCGGGATCGCCGCCCTGGCGCGCGACACCGGCGCCACCGTGGTGGCCAGCCGGCGCGGCGCGGAG
GGCCTGCGGGCAGGCGCGCATGCGAAGGACGATCCGCAATTCGACTATGGCGGCGCCTGGCCGGCGGTGTCGCGGCTGCGCGTCATGAAG
GACGGAGAGGTTCTGAGGATCGGCCGCGCATCCATCACCGCGCATGCGACGCCGGGCCACACGATGGGCAGCATGACATGGAGCTGGAAC
GCCTGCGAGGGCAAGAGGTGCAAGGCGATCGTCTTCGCCTCCAGCCTCAATCCGGTGTCGGCCGACCGTTACCGTTTCACCGCGCCTTCC
AGCGCGCCGATCGTCAAGGGCTTCGAAGCCAGCTACAGGCGCATGGGCGCTTTGAAGTGCGACATTTTGATCTCCGCGCATCCCGACAAT
GCGGGCGCGGGGCGGTATGGCAGTGGATCCGGGGCCTGCCGGTCCTATGCGGAACGTTCGCGCCGCCTGCTCGCGAAGCGGTTGGCCGAG
GAGCGGCGAGAGACGTCGAAATAG

Curator Acknowledgements
Curator Description Most Recent Edit