| Accession | ARO:3001399 |
| CARD Short Name | OXA-4 |
| Definition | OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa. |
| AMR Gene Family | OXA beta-lactamase, OXA-1-like beta-lactamase |
| Drug Class | penam, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Aeromonas veroniiwgs, Burkholderia cenocepaciag, Escherichia colip+wgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosag+wgs+gi, Salmonella entericawgs |
| Resistomes with Sequence Variants | Aeromonas veroniiwgs, Burkholderia cenocepaciag, Enterobacter hormaecheigi, Escherichia colip+wgs+gi, Klebsiella huaxiensisgi, Klebsiella pneumoniaewgs+gi, Morganella morganiigi, Pasteurella multocidagi, Proteus mirabilisgi, Pseudomonas aeruginosag+wgs+gi, Salmonella entericawgs+gi, Shigella dysenteriaegi, Shigella flexnerigi |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + beta-lactam antibiotic + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + penam [Drug Class] + beta-lactamase + oxacillin [Antibiotic] + cephem + class D beta-lactamase + OXA beta-lactamase [AMR Gene Family] + cephalosporin [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + OXA-1-like beta-lactamase [AMR Gene Family] |
| Publications | Kingsley SA, et al. 2013. Indian J Microbiol 53(3): 308-314. First Report of OXA-4, an ESBL Isolated from Pseudomonas aeruginosa a South Indian Strain. (PMID 24426128) |
Prevalence of OXA-4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas veronii | 0% | 0% | 0.56% | 0% |
| Burkholderia cenocepacia | 0.5% | 0% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0% | 6.67% |
| Escherichia coli | 0% | 0.01% | 0.03% | 1.28% |
| Klebsiella huaxiensis | 0% | 0% | 0% | 50% |
| Klebsiella pneumoniae | 0% | 0% | 0.03% | 5.71% |
| Morganella morganii | 0% | 0% | 0% | 7.69% |
| Pasteurella multocida | 0% | 0% | 0% | 16.67% |
| Proteus mirabilis | 0% | 0% | 0% | 22.22% |
| Pseudomonas aeruginosa | 1.53% | 0% | 0.84% | 8.33% |
| Salmonella enterica | 0% | 0% | 0.07% | 3.64% |
| Shigella dysenteriae | 0% | 0% | 0% | 25% |
| Shigella flexneri | 0% | 0% | 0% | 16.67% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500