rosA

Accession ARO:3003048
DefinitionrosA is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classpeptide antibiotic, tetracycline antibiotic, fosfomycin, isoniazid, penam, acridine dye, phenicol antibiotic, lincosamide antibiotic, diaminopyrimidine antibiotic, benzalkonium chloride, rifamycin antibiotic, nucleoside antibiotic, nitroimidazole antibiotic, glycylcycline, fluoroquinolone antibiotic, macrolide antibiotic, rhodamine, antibacterial free fatty acids, bicyclomycin, cephalosporin, oxazolidinone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification39 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Bengoechea JA, et al. 2000. Mol Microbiol 37(1): 67-80. Temperature-regulated efflux pump/potassium antiporter system mediates resistance to cationic antimicrobial peptides in Yersinia. (PMID 10931306)

Resistomes

Prevalence of rosA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 770


>gb|AAC60781.1|-|rosA [Yersinia enterocolitica (type O:8)]
MTDRSETELPPSVNTQPFDNTKVKRTSFSILGAISVSHLLNDMIQSLILAIYPLLQAEFSLSFAQIGLITLTYQLTASLLQPLIGLYTDK
HPQPYSLPIGMGFTLSGILLLAVATTFPGGFTWHAALVGTGSSVFHPESSRVAARLPVAATVWLSLFLGGRQFRQRLGPLLAAILIAPYG
KGNVGWFSLAALLAIVVLLQVSKWYQQQQRATYGKVVKVSSAKILPKKTVISALAILMVLIFSKYFYLTSISSYYTFYLMHKFGVSVQNA
QIHLFVFLFAVAAGTIIGGPLGDRIGRKYVIWGSILGVAPFTLILPYVSLYWTGVLTVIIGLILASAFSAILVYAQELIPGKVGMVSGLF
FGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLLGIITVFLPNIEDK


>gb|U46859.1|-|24295-25527|rosA [Yersinia enterocolitica (type O:8)]
ATGACCGATCGTTCTGAGACGGAGCTCCCTCCCTCCGTCAATACCCAGCCCTTCGATAATACCAAGGTAAAACGCACCTCTTTCTCTATA
TTAGGTGCTATTAGCGTATCTCACTTACTTAACGATATGATCCAGTCGCTGATTCTGGCGATTTATCCGCTATTACAAGCCGAGTTTTCG
CTGAGTTTTGCGCAGATTGGATTAATCACCCTCACTTATCAGCTTACCGCCTCATTATTACAGCCACTTATTGGTCTTTATACCGATAAG
CATCCGCAGCCCTATTCACTGCCGATTGGCATGGGTTTCACCTTATCAGGTATCTTGCTGCTTGCGGTTGCCACGACTTTCCCAGGTGGT
TTTACATGGCATGCGGCATTAGTCGGAACCGGTTCTTCGGTCTTCCACCCAGAATCCTCACGCGTAGCCGCTAGGCTACCGGTGGCCGCC
ACGGTATGGCTCAGTCTATTTTTGGGTGGGAGGCAATTTCGGCAGCGCCTTGGCCCACTATTAGCCGCGATCCTTATCGCACCTTACGGT
AAAGGCAATGTAGGTTGGTTTTCACTCGCGGCACTGCTGGCTATTGTGGTGCTGTTGCAGGTCAGTAAATGGTATCAGCAACAACAAAGA
GCAACCTATGGCAAAGTAGTAAAAGTCTCATCGGCCAAAATACTGCCTAAAAAGACGGTTATTAGCGCCCTAGCTATCTTAATGGTGCTG
ATATTCTCTAAATACTTCTACTTGACCAGTATTAGTAGCTATTACACCTTTTATTTGATGCATAAGTTTGGTGTTTCGGTACAAAATGCC
CAAATACATTTATTTGTCTTCTTATTCGCAGTGGCCGCTGGCACCATCATTGGCGGCCCTCTTGGCGATAGGATAGGTCGAAAGTATGTT
ATTTGGGGGTCAATATTGGGCGTTGCGCCATTTACCCTTATTTTACCCTACGTTTCTCTGTATTGGACCGGGGTTTTAACCGTGATCATT
GGCCTTATCCTTGCCTCTGCCTTCTCGGCAATACTGGTGTATGCGCAAGAGCTTATTCCGGGTAAAGTGGGCATGGTATCCGGTCTATTC
TTCGGTTTTGCTTTCGGTATGGGGGGGTTAGGTGCGGCTGTACTAGGGTATGTTGCTGATTTAACCAGTATTGAACTGGTTTATCAAATA
TGCGCCTTCTTACCATTACTGGGGATAATTACGGTCTTCCTGCCCAATATAGAAGATAAGTAA