MexJ

Accession ARO:3003692
DefinitionmexJ is the membrane fusion protein of the MexJK multidrug efflux protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, aminocoumarin antibiotic, acridine dye, antibacterial free fatty acids, penam, glycylcycline, triclosan, diaminopyrimidine antibiotic, aminoglycoside antibiotic, phenicol antibiotic, fluoroquinolone antibiotic, carbapenem, monobactam, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification25 ontology terms | Show
Parent Term(s)3 ontology terms | Show
Publications

Chuanchuen R, et al. 2002. J. Bacteriol. 184(18):5036-44 The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan. (PMID 12193619)

Resistomes

Prevalence of MexJ among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Escherichia coli0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 690


>gb|AAG07065.1|-|mexJ [Pseudomonas aeruginosa PAO1]
MYRHIPLVALSLFSSLFLAACGNGTPPPAAARPAIVVQPQPAGEVSQAFPGEIRARHEPELAFRIGGKVIRRLVEVGERVKKDQPLAELD
PQDVRLQLEAARAQVSAAEANLQTVRAEYRRYRTLLDRNLVSHSQFENIQNSYRAGEARLKQIRAEFNVADNQAGYAVLRSPQDGVIASR
RVEVGQVVAAGQTVFSLAADGEREVLIGLPEHSFERFRIGQPVSVELWSQRDRRFAGHIRELSPAADPQSRTFAARVAFDDRATPAELGQ
SARVYVAAAEAVPLSVPLSALTAEAGQAFVWVVEPGSSTLRRQAVRTGPYAEDRVPVLEGLKAGDWVVATGVQVLREGQQVRPIDRANRT
VKLAAKE


>gb|AE004091.2|-|4119270-4120373|mexJ [Pseudomonas aeruginosa PAO1]
ATGTACCGCCATATCCCGCTCGTCGCCCTGTCCCTGTTTTCCTCCCTGTTCCTCGCCGCCTGCGGCAACGGCACGCCGCCGCCAGCCGCG
GCGCGTCCGGCGATCGTCGTCCAGCCCCAGCCGGCGGGGGAGGTGAGCCAGGCCTTTCCCGGCGAGATCCGCGCCCGCCACGAGCCGGAG
CTGGCCTTCCGCATCGGCGGCAAGGTCATCCGCCGGCTGGTGGAAGTCGGCGAGCGGGTAAAGAAGGACCAGCCCCTGGCCGAACTCGAT
CCCCAGGACGTGCGCCTGCAACTGGAGGCGGCGCGGGCCCAGGTCAGTGCCGCCGAGGCCAACTTGCAGACCGTGCGCGCCGAGTACCGG
CGCTACCGCACCTTGCTCGACCGCAACCTGGTCAGCCATTCCCAGTTCGAGAACATCCAGAACAGCTACCGCGCCGGCGAGGCGCGGCTG
AAGCAGATCCGCGCCGAATTCAACGTCGCCGACAACCAGGCCGGCTACGCCGTGCTGCGCTCGCCCCAGGATGGCGTGATCGCCAGCCGG
CGCGTCGAGGTGGGCCAGGTGGTGGCGGCCGGACAGACGGTCTTCAGCCTGGCCGCCGACGGCGAACGCGAGGTGCTGATCGGCCTGCCG
GAACACAGCTTCGAACGTTTCCGCATCGGCCAGCCGGTGTCGGTCGAACTCTGGTCGCAACGCGACAGACGCTTCGCCGGGCATATCCGC
GAGCTCTCGCCCGCGGCCGATCCGCAATCGCGTACCTTCGCCGCCCGGGTGGCCTTCGACGACCGCGCGACTCCGGCCGAACTGGGCCAG
AGCGCGCGGGTCTACGTCGCCGCCGCCGAGGCGGTGCCGTTATCGGTTCCCTTGTCGGCGCTGACCGCAGAGGCCGGCCAGGCGTTCGTC
TGGGTGGTCGAGCCGGGCAGCTCGACCCTGCGCCGGCAGGCGGTGCGCACCGGTCCCTATGCCGAGGACCGGGTGCCGGTGCTCGAAGGC
CTGAAGGCTGGCGACTGGGTGGTGGCCACCGGGGTCCAGGTGCTTCGCGAAGGGCAGCAGGTGCGTCCGATCGACCGGGCCAACCGCACG
GTGAAACTGGCGGCCAAGGAGTAG