MexK

Accession ARO:3003693
DefinitionmexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, diaminopyrimidine antibiotic, aminoglycoside antibiotic, carbapenem, monobactam, aminocoumarin antibiotic, acridine dye, triclosan, phenicol antibiotic, penam, macrolide antibiotic, glycylcycline, fluoroquinolone antibiotic, antibacterial free fatty acids
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesPseudomonas fluorescensg
Classification25 ontology terms | Show
Parent Term(s)3 ontology terms | Show
Publications

Chuanchuen R, et al. 2002. J. Bacteriol. 184(18):5036-44 The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan. (PMID 12193619)

Resistomes

Prevalence of MexK among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Enterobacter cloacae0%0%0%
Escherichia coli0%0%0%
Proteus mirabilis0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1900


>gb|AAG07064.1|-|mexK [Pseudomonas aeruginosa PAO1]
MSFNLSAWALQNRQIVLYLMILLGAVGALSYSKLGQSEDPPFTFKAMVVQTNWPGASAEEVARQVTERIEKKLMETGDYDRIVSFSRPGV
SQVTFMAREDIHSSEIPELWYQIRKKISDIRATLPQSIQGPFFNDEFGTTYGNIYALTGKGFDYAVMKDYADRLQLQLQRIRNVGKVELI
GLQDEKIWIDLSNTKLATLGLPLAAVQKALEEQNAVASSGFFETASDRVQLRVSGRFDSVEEIRDFPIRVGDRTFRIGDVAEVRRGFNDP
PAPRMRFMGEDAIGLAVAMKPGGDILVLGKALETEFARLQQSLPAGLELRKVSDQPAAVRTGVGEFIRVLAEALVIVLLVSFFSLGLRTG
LVVALSIPLVLAMTFAAMHYFGIGLHKISLGALVLALGLLVDDAIIAVEMMAVKMEQGYDRLKAASFAWTSTAFPMLTGTLITAAGFLPI
ATAQSGTGEYTRSLFQVVTIALVVSWFAAVVFVPYLGAKLLPDLARLHAQKHGGSADGYDPYATAFYQRFRRLVEWCVRYRKTVIVLTLA
AFVGALLLFRLVPQQFFPPSARLELLLDIKLAEGASLRSTGEEVQRLEKMLQGHDGIDNYVAYVGTGSPRFYLPLDQQLPAASFAQVVVL
AKDLESREALRKWLIERMNEDFPHLRSRISRLENGPPVGYPVQFRVSGEDIPQVRELARKVADKMRENPHVVNVHLDWEEPSKVVYLSID
QERARALGVSTASLSQFLQSALTGSHVSFFREDNELIEILLRGTEQERRDLSLLPSLAVPTENGRSVALSQIATLEYGFEEGIIWHRNRL
PTVTVRADIYDDSLPATLVAQIAPTLEPIRAELPDGYLLEVGGTVEDAAKGQSSVNAGVPLFIVVVLSLLMVQLRSFSRMAMVFLTAPLG
LIGVTLFLLLFRQPFGFVAMLGTIALAGMIMRNSVILVDQIEQDISHGLDRWHAIIEATVRRFRPIVLTALAAVLAMIPLSRSVFFGPMA
VAIMGGLIVATVLTLLFLPALYAAWFRVKKDEARA


>gb|AE004091.2|-|4116188-4119265|mexK [Pseudomonas aeruginosa PAO1]
ATGTCCTTCAACCTTTCCGCCTGGGCGTTGCAGAATCGCCAGATCGTCCTGTACCTGATGATCCTGCTTGGCGCGGTCGGCGCGCTGTCC
TACAGCAAGCTGGGGCAGAGCGAAGACCCGCCGTTCACCTTCAAGGCCATGGTGGTGCAGACCAACTGGCCGGGCGCCAGCGCCGAAGAG
GTGGCCCGGCAGGTCACCGAGCGTATCGAGAAGAAGCTGATGGAAACCGGCGACTACGATCGCATCGTGTCCTTCTCCCGCCCCGGCGTC
TCGCAGGTGACCTTCATGGCCCGCGAGGACATCCATTCCAGCGAGATCCCCGAACTCTGGTACCAGATCCGCAAGAAGATCAGCGACATT
CGCGCCACCTTGCCGCAAAGCATCCAGGGCCCGTTCTTCAACGACGAGTTCGGCACCACCTACGGCAACATCTATGCGCTCACCGGCAAG
GGCTTCGACTACGCGGTGATGAAGGACTATGCCGACCGCCTGCAACTGCAATTGCAGCGGATCAGGAACGTCGGCAAGGTCGAGCTGATC
GGCCTGCAGGACGAGAAGATCTGGATCGACCTGTCCAACACCAAGCTGGCCACCCTCGGCCTGCCCCTGGCGGCGGTACAGAAGGCGCTG
GAGGAACAGAACGCGGTGGCCTCCTCCGGGTTCTTCGAGACCGCCAGCGACCGCGTGCAGTTGCGCGTTTCCGGGCGTTTCGATTCGGTG
GAGGAGATCCGCGACTTCCCCATCCGCGTCGGCGACCGCACCTTCCGCATCGGCGACGTGGCCGAGGTTCGCCGCGGCTTCAACGATCCG
CCGGCGCCGCGCATGCGCTTCATGGGCGAGGACGCCATCGGCCTGGCGGTAGCGATGAAGCCGGGCGGCGACATCCTGGTGCTGGGCAAG
GCCCTGGAAACCGAGTTCGCCCGCCTGCAGCAGTCGCTGCCGGCCGGACTGGAACTGCGCAAGGTGTCCGACCAGCCGGCGGCGGTACGT
ACCGGGGTCGGCGAGTTCATCCGGGTGCTGGCCGAGGCGCTGGTGATCGTCCTGCTGGTGAGCTTCTTCTCCCTCGGCCTGCGCACCGGC
CTGGTGGTGGCGCTGTCGATCCCGCTGGTGCTGGCGATGACCTTCGCCGCCATGCATTACTTCGGCATCGGCCTGCACAAGATCTCCCTC
GGCGCCCTGGTGCTGGCGCTGGGATTACTGGTGGACGACGCGATCATCGCGGTGGAGATGATGGCGGTGAAGATGGAGCAGGGCTACGAC
CGCCTCAAGGCGGCCAGCTTCGCCTGGACCAGCACCGCCTTCCCGATGCTCACCGGCACCCTGATCACCGCCGCCGGCTTCCTGCCGATC
GCCACCGCGCAGTCCGGCACCGGCGAATACACCCGCTCGTTGTTCCAGGTGGTGACCATCGCCCTGGTGGTCTCCTGGTTCGCCGCGGTG
GTCTTCGTTCCCTACCTGGGGGCCAAGCTGCTGCCGGACCTGGCCAGGTTGCACGCGCAGAAGCACGGCGGCAGCGCCGATGGCTACGAT
CCCTATGCTACGGCCTTCTACCAGCGCTTCCGGCGTCTGGTGGAGTGGTGCGTGCGCTACCGCAAGACGGTGATCGTCCTGACTCTCGCG
GCCTTCGTCGGCGCGCTGCTGCTGTTCCGCCTGGTGCCGCAGCAGTTCTTCCCGCCCTCGGCGCGCCTGGAGCTGCTGCTGGACATCAAG
CTGGCGGAGGGTGCCTCACTGCGCTCTACCGGCGAGGAAGTCCAGCGCCTGGAAAAAATGCTGCAGGGCCATGACGGCATCGACAACTAC
GTGGCCTACGTCGGCACCGGCTCGCCCCGCTTCTACCTGCCGCTGGACCAGCAATTGCCGGCGGCCAGCTTCGCCCAGGTGGTGGTGCTG
GCCAAGGACCTGGAGAGCCGCGAGGCGCTGCGCAAGTGGCTGATCGAGCGGATGAACGAGGACTTCCCGCACCTGCGCAGCCGCATCAGT
CGCCTGGAGAACGGGCCGCCGGTGGGCTATCCGGTGCAGTTCCGGGTTTCCGGCGAGGACATCCCGCAGGTTCGCGAACTGGCGCGCAAG
GTCGCCGACAAGATGCGCGAGAACCCGCACGTGGTGAATGTGCACCTGGATTGGGAAGAGCCGAGCAAGGTGGTGTACCTGAGCATCGAC
CAGGAGCGCGCCCGTGCCCTGGGGGTGAGCACCGCCAGCCTGTCGCAGTTCCTGCAGAGCGCGCTGACCGGCTCGCACGTGAGCTTCTTC
CGCGAAGACAACGAGCTGATCGAGATCCTCCTGCGCGGCACCGAGCAGGAGCGTCGTGACCTGTCGTTGCTGCCGAGCCTGGCGGTGCCG
ACCGAGAATGGCCGGAGCGTGGCGCTGTCGCAGATCGCTACGCTCGAATACGGCTTCGAAGAGGGCATCATCTGGCACCGCAACCGCCTG
CCGACGGTCACCGTGCGCGCCGATATCTACGACGATTCGCTGCCGGCGACCCTGGTCGCGCAGATCGCCCCGACCCTGGAACCGATCCGC
GCCGAGTTGCCGGACGGCTACCTGCTGGAGGTGGGCGGCACGGTGGAGGACGCGGCGAAGGGCCAGAGTTCGGTGAACGCCGGCGTGCCG
CTGTTCATCGTGGTGGTGTTGAGCCTGCTGATGGTGCAGTTGCGCAGCTTCTCGCGGATGGCGATGGTATTCCTCACCGCACCGCTGGGC
CTGATCGGCGTGACCCTGTTCCTGCTGCTGTTCCGCCAGCCGTTCGGCTTCGTGGCGATGCTCGGGACCATCGCCCTGGCCGGCATGATC
ATGCGCAACTCGGTGATCCTGGTGGACCAGATCGAACAGGACATCAGCCATGGACTGGATCGCTGGCACGCCATCATCGAGGCTACCGTG
CGGCGTTTCAGGCCCATCGTGCTGACCGCGCTGGCGGCGGTGCTGGCGATGATCCCGCTGTCGCGCAGCGTGTTCTTCGGGCCGATGGCG
GTGGCGATCATGGGCGGGCTGATCGTCGCCACCGTGCTCACCCTGCTGTTCCTGCCGGCGCTCTATGCCGCCTGGTTCCGCGTGAAGAAG
GACGAGGCGCGGGCCTGA