OXA-899

Accession ARO:3005093
CARD Short NameOXA-899
DefinitionOXA-899 is a class D beta-lactamase and part of the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii.
AMR Gene FamilyOXA beta-lactamase, OXA-22-like beta-lactamase
Drug Classpenam, cephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesRalstonia pickettiiwgs
Resistomes with Sequence VariantsRalstonia pickettiiwgs
Classification16 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ OXA-22-like beta-lactamase [AMR Gene Family]
Publications

Jiang T, et al. 2020. J Glob Antimicrob Resist 21:46-48 Genotypic and phylogenetic characterisation of a clinical Ralstonia pickettii strain carrying two novel OXA allelic variants, blaOXA-898 and blaOXA-899, isolated from a bloodstream infection in China. (PMID 32169680)

Resistomes

Prevalence of OXA-899 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Ralstonia pickettii0%0%5.06%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 530


>gb|QHT72949.1|+|OXA-899 [Ralstonia pickettii]
MMKRRHAATGALLAALATFAHAEHPICTIVADGATGKAVLQEGRCDERVTPASTFKLALAVMGFDHGFLKDEHTPVEHFRHGDPDWGGEA
WHQPIDPALWLKYSVVWYSQRITHAMGAQTFQAYVRKLGYGNMDVSGDPGKNNGMDRSWITSSLKISPEEQVGFMRRIVNRQLPVSARTY
EMVDRTVQTWQVPGGWSVHGKTGTAGPAPGNTSPDGTWDQAHAYGWFVGWARKGDKTYVFANLIQDDKVEPTSGGIRSRDALLARLPEVL
AFAGQ


>gb|MN968729.1|+|1-828|OXA-899 [Ralstonia pickettii]
ATGATGAAACGCCGCCACGCCGCCACCGGCGCCCTGCTTGCTGCGCTTGCAACCTTTGCCCACGCCGAGCACCCGATCTGCACGATCGTG
GCCGATGGCGCGACGGGCAAGGCAGTCTTGCAAGAAGGCAGGTGCGACGAGCGCGTGACCCCCGCTTCCACCTTCAAGCTGGCGCTGGCC
GTCATGGGCTTTGACCACGGCTTCCTGAAAGACGAGCACACCCCGGTGGAGCACTTCAGGCACGGTGACCCCGACTGGGGCGGCGAGGCT
TGGCACCAGCCGATCGACCCGGCGCTGTGGCTCAAGTATTCGGTGGTCTGGTATTCGCAGCGCATTACGCATGCGATGGGCGCGCAGACC
TTCCAGGCCTACGTGCGCAAGCTCGGCTACGGCAACATGGATGTGAGCGGCGATCCGGGCAAGAACAACGGCATGGACCGCTCGTGGATC
ACCTCGTCGCTGAAGATCTCGCCGGAGGAGCAAGTCGGCTTCATGCGCAGGATCGTCAACCGGCAGTTGCCGGTGTCGGCGCGCACCTAC
GAGATGGTCGACCGTACCGTGCAGACCTGGCAGGTGCCGGGCGGCTGGTCAGTGCACGGCAAGACGGGCACCGCCGGCCCTGCGCCGGGC
AATACCTCGCCCGATGGCACGTGGGACCAGGCGCACGCTTACGGGTGGTTTGTCGGCTGGGCCAGGAAGGGCGACAAGACGTACGTGTTT
GCCAACCTGATCCAGGACGACAAGGTTGAGCCGACCTCGGGCGGCATCCGCTCGCGCGATGCGCTGCTTGCGCGCCTGCCCGAAGTGCTT
GCCTTTGCCGGGCAATGA