penicillin [Antibiotic]

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Accession ARO:0000054
Synonym(s)Liquacillin Benzopenicillin Pradupen penicillin g Benzylpenicillin PCN Specilline G Gelacillin Cilopen Pharmacillin Dropcillin
DefinitionPenicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.
Drug Classpenam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penam [Drug Class]
Sub-Term(s)
5 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ ACI-1 confers_resistance_to_antibiotic
+ MtrCDE confers_resistance_to_antibiotic
+ Escherichia coli ampC beta-lactamase confers_resistance_to_antibiotic
+ Neisseria gonorrhoea PBP1 conferring resistance to beta-lactam confers_resistance_to_antibiotic
Publications

Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804)

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)