| Accession | ARO:0000054 |
| Synonym(s) | Benzopenicillin Cilopen Dropcillin Gelacillin Liquacillin PCN penicillin g Pharmacillin Pradupen Specilline G |
| Definition | Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. |
| Drug Class | penam |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + penam [Drug Class] |
| Sub-Term(s) | 9 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + ACI-1 confers_resistance_to_antibiotic + MtrCDE confers_resistance_to_antibiotic + Escherichia coli ampC beta-lactamase confers_resistance_to_antibiotic + Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + SCO-1 confers_resistance_to_antibiotic + TEM-135 confers_resistance_to_antibiotic + Neisseria gonorrhoeae porin PIB (por) confers_resistance_to_antibiotic + mecC-type BlaZ confers_resistance_to_antibiotic |
| Publications | Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804) Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791) |
