| Accession | ARO:3000246 |
| CARD Short Name | vanC_cluster |
| Definition | Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
| Sub-Term(s) | 5 ontology terms | Show + vanC part_of + vanR gene in vanC cluster part_of + vanS gene in vanC cluster part_of + vanT gene in vanC cluster part_of + vanXY gene in vanC cluster part_of |
| Publications | Navarro F and Courvalin P. 1994. Antimicrob Agents Chemother 38(8): 1788-1793. Analysis of genes encoding D-alanine-D-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. (PMID 7986009) Dutka-Malen S, et al. 1992. Gene 112(1): 53-58. Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. (PMID 1551598) Arias CA, et al. 2000. Antimicrob Agents Chemother 44(6): 1660-1666. vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174. (PMID 10817725) Arias CA, et al. 2003. J Antimicrob Chemother 51(3): 557-564. Role of the transmembrane domain of the VanT serine racemase in resistance to vancomycin in Enterococcus gallinarum BM4174. (PMID 12615855) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) |
Prevalence of glycopeptide resistance gene cluster VanC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster VanC
Model Description:
Regulatory: vanR gene in vanC clustervanS gene in vanC cluster
Core: vanCvanXY gene in vanC clustervanT gene in vanC cluster