| Accession | ARO:3000606 |
| CARD Short Name | FEZ-1 |
| Definition | FEZ-1 is an Ambler class B MBL; subclass B3 first isolated from Legionella gormanii. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. |
| AMR Gene Family | FEZ beta-lactamase |
| Drug Class | penam, carbapenem, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Legionella anisag+wgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + hydrolysis of antibiotic conferring resistance + antibiotic molecule + antibiotic inactivation enzyme + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactamase + beta-lactam antibiotic + class B (metallo-) beta-lactamase + cephem + subclass B3 (metallo-) beta-lactamase + penam [Drug Class] + carbapenem [Drug Class] + cephalosporin [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + FEZ beta-lactamase [AMR Gene Family] |
| Publications | Lienard BM, et al. 2008. Org Biomol Chem 6(13): 2282-2294. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. (PMID 18563261) García-Sáez I, et al. 2003. J. Mol. Biol. 325(4):651-60 Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. (PMID 12507470) |
Prevalence of FEZ-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Legionella anisa | 100% | 0% | 100% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500