| Accession | ARO:3004124 |
| CARD Short Name | Mcat_M35_AMX |
| Definition | The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Down-regulation of M35 significantly increases the MICs of aminopenicillins, specifically amoxicillin. |
| AMR Gene Family | General Bacterial Porin with reduced permeability to beta-lactams |
| Drug Class | penam, cephalosporin, penem, carbapenem, cephamycin, monobactam |
| Resistance Mechanism | reduced permeability to antibiotic, resistance by absence |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + beta-lactam antibiotic + determinant of antibiotic resistance + cephem + protein modulating permeability to antibiotic + penam [Drug Class] + cephalosporin [Drug Class] + General Bacterial Porin (GBP) + penem [Drug Class] + carbapenem [Drug Class] + resistance by absence [Resistance Mechanism] + cephamycin [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + gene conferring resistance via absence + confers_resistance_to_antibiotic amoxicillin [Antibiotic] + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] |
| Publications | Jetter M, et al. 2010. J. Antimicrob. Chemother. 65(10):2089-96 Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins. (PMID 20801781) Easton DM, et al. 2005. J. Bacteriol. 187(18):6528-35 Characterization of a novel porin protein from Moraxella catarrhalis and identification of an immunodominant surface loop. (PMID 16159786) |
Prevalence of Moraxella catarrhalis M35 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein knockout model
Model Definition: Protein Knockout Models (PKM) reflect resistance by the absence of a gene product, most often deletion of a gene involved in antibiotic import, such as Vibrio cholerae OmpT. Like Protein Homolog Models (PHMs), PKMs include a reference sequence and a bitscore cut-off for detection using BLASTP but instead are designed to only report lack of detection under Perfect or Strict criteria. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software.
Bit-score Cut-off (blastP): 650
Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded