MexW

Accession ARO:3003031
DefinitionMexW is the RND-type membrane protein of the efflux complex MexVW-OprM.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, antibacterial free fatty acids, phenicol antibiotic, macrolide antibiotic, acridine dye, diaminopyrimidine antibiotic, glycylcycline, monobactam, aminocoumarin antibiotic, aminoglycoside antibiotic, carbapenem, penam, fluoroquinolone antibiotic, triclosan
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification27 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Li Y, et al. 2003. J Antimicrob Chemother 52(4): 572-575. A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa. (PMID 12951344)

Resistomes

Prevalence of MexW among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Citrobacter freundii0%0%0%
Enterobacter cloacae0%0%0%
Escherichia coli0%0%0%
Klebsiella pneumoniae0%0%0%
Legionella pneumophila0%0%0.14%
Morganella morganii0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Vibrio vulnificus0%0%2.03%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1900


>gb|AAG07763.1|+|mexW [Pseudomonas aeruginosa PAO1]
MAFTDPFIRRPVLASVVSLLIVLLGMQAFSKLVIREYPQMENALITVTTLYAGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNYST
ISIYARIGANTDRLVTELLAKSNEVKSQLPPDAEDPVLQKEAADASALMYISFYSEQMNNPQITDYLSRVIQPKLATLPGIAEAEILGNQ
VFAMRLWLDPVKMAAFGVTAGEINQAVQQYNFLAAAGEVKGQLVVTSVNASTDLKSPQAFAAIPVKTDGDRRVLMGDVARVELGAASYDA
ISSFNGIPSVYIGIKGTPSANPLDVIKEVRAKMPELEEQLPPNLKVSIAYDATRFIQASIDEVVKTLGEAVLIVIVVVFLFLGAFRSVLI
PVVTIPLSMIGVLFFMQAMGYSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGKPPFEAALEGAREIAVPVVSMTITLAAVYAPIGF
LTGLTGALFKEFAFTLAGAVIISGIVALTLSPMMCSRLLRHEENPSGLAHRLDLIFEGLKQRYQRALHGTLDTRPVVLVFAVLVLALIPV
LLMFTKKELAPEEDQGIVFLMTNSPQTANLDYLNRYTAEFEGIFRSFPEYYSAFQINGYNGVQAGIGGMLLKPWDEREKSQMELLHAVQA
KLNEIPGVQIFAFNLPSLPGTGEGLPFQFVLNTANDYESLLQVAQRVKQRASESGKFAFLDLDLAFDKPELVVDIDREKAAQMGVSMQDL
GVALASLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLGSYYVKSRNGQLVALSTLIETHERARPRQLNQFQQLNSAIISGFPIVSMG
EAIETVQQIAREEAPRGFAVDYAGASRQYVQEGSALLVTFGLALAIIFLVLAAQFESFRDPLVIMVTVPLSICGALIPLFLGVSSLNIYT
QVGLVTLIGLISKHGILIVEFANQLRHEQGLGRREAIEQAAAIRLRPVLMTTAAMVLGVIPLILATGAGAVSRFDIGIVIATGMSVGTLF
TLFVLPCIYTLVARPDAPPGVTQAANAH


>gb|NC_002516.2|+|4904647-4907703|mexW [Pseudomonas aeruginosa PAO1]
ATGGCTTTTACCGATCCGTTCATCCGTCGTCCGGTCCTGGCGAGCGTGGTCAGCCTGCTGATCGTCCTGCTCGGCATGCAGGCCTTCAGC
AAGCTGGTGATCCGCGAGTATCCGCAAATGGAGAACGCGCTGATCACGGTGACCACGCTCTACGCCGGCGCCAACGCGGAAACCATCCAG
GGCTACATCACCCAGCCGCTGCAGCAGAGCCTGGCCAGCGCCGAAGGCATCGACTACATGACCTCGGTGAGCCGGCAGAACTATTCGACC
ATCTCCATCTACGCGCGGATCGGCGCCAATACCGATCGCCTGGTCACCGAGCTGCTGGCCAAGTCCAACGAAGTGAAGAGCCAGCTGCCG
CCGGACGCCGAGGACCCGGTGCTGCAGAAGGAGGCCGCGGACGCCTCGGCGCTGATGTACATCAGCTTCTACAGCGAGCAGATGAACAAC
CCGCAGATCACCGACTACCTGTCGCGGGTGATCCAGCCCAAGCTGGCGACCCTGCCCGGTATCGCCGAGGCGGAGATCCTCGGCAACCAG
GTGTTCGCCATGCGCCTGTGGCTGGACCCGGTGAAGATGGCCGCGTTCGGCGTCACCGCCGGCGAGATCAACCAGGCGGTGCAGCAGTAC
AACTTCCTCGCCGCCGCCGGCGAGGTGAAGGGCCAGTTGGTGGTCACCAGCGTCAATGCTTCCACCGACCTCAAGTCGCCCCAGGCCTTC
GCCGCCATCCCGGTGAAGACCGACGGCGACCGCCGGGTGCTGATGGGTGATGTCGCACGGGTCGAACTGGGCGCCGCCAGCTACGACGCG
ATCAGTTCGTTCAATGGGATTCCCTCGGTCTACATCGGCATCAAGGGCACGCCCAGCGCCAACCCGCTGGACGTGATCAAGGAAGTGCGG
GCGAAGATGCCCGAACTGGAAGAGCAATTGCCGCCCAACCTCAAGGTGTCCATCGCCTACGACGCCACGCGCTTCATTCAGGCCTCCATC
GATGAAGTGGTGAAGACCCTCGGCGAGGCGGTGCTGATCGTCATCGTGGTGGTGTTCCTGTTCCTCGGCGCGTTCCGTTCGGTACTGATC
CCGGTGGTGACCATTCCGCTGTCGATGATCGGCGTATTGTTCTTCATGCAGGCCATGGGCTACTCGATCAACCTGCTGACCCTGCTGGCG
ATGGTCCTGGCCATCGGCCTGGTGGTGGACGACGCGATCGTGGTGGTGGAAAACATCCACCGCCACATCGAGGAGGGCAAGCCGCCCTTC
GAGGCTGCCCTGGAGGGCGCGCGGGAGATCGCCGTACCGGTGGTCAGCATGACCATCACCCTCGCCGCGGTCTACGCGCCGATCGGCTTC
CTCACCGGCCTCACCGGCGCCCTGTTCAAGGAGTTCGCCTTCACCCTGGCCGGCGCGGTGATCATTTCCGGGATCGTCGCCCTGACCCTG
TCGCCGATGATGTGCTCGCGCCTGTTGCGCCACGAGGAGAATCCCTCGGGCCTGGCGCATCGCCTCGACCTGATCTTCGAGGGCCTGAAG
CAACGCTACCAGCGCGCCCTCCACGGCACCCTGGACACCCGTCCGGTGGTCCTGGTGTTCGCCGTGCTGGTACTGGCGCTGATCCCGGTA
CTGCTGATGTTCACCAAGAAGGAGCTGGCGCCGGAAGAGGACCAGGGCATCGTGTTCCTCATGACCAACTCGCCGCAAACCGCCAACCTC
GACTACCTGAATCGCTACACCGCCGAGTTCGAAGGCATCTTCCGCAGCTTCCCGGAGTATTACTCGGCGTTCCAGATCAACGGCTACAAC
GGCGTCCAGGCCGGCATCGGCGGCATGCTGCTCAAGCCCTGGGACGAACGCGAAAAGAGCCAGATGGAATTGCTCCATGCGGTGCAGGCG
AAGCTCAACGAGATTCCCGGCGTGCAGATCTTCGCCTTCAACCTGCCGTCGCTACCGGGCACCGGCGAGGGCCTGCCATTCCAGTTCGTG
CTCAACACCGCCAACGACTACGAGTCGCTGCTGCAAGTGGCGCAACGGGTGAAGCAGCGCGCCAGCGAGTCCGGCAAGTTCGCCTTCCTC
GATCTCGACCTGGCGTTCGACAAACCCGAGCTGGTGGTCGACATCGACCGCGAGAAGGCCGCGCAGATGGGCGTCTCCATGCAGGACCTG
GGGGTGGCGCTGGCCAGCCTGCTCGGCGAGGGCGAGATCAACCGCTTCACCATCGACGGGCGCAGCTACAAGGTCATCGCCCAGGTCGAA
CGCCCCTATCGCGACAATCCCGGCTGGCTCGGCAGCTACTACGTGAAGAGCCGCAACGGCCAACTGGTCGCCCTCTCGACCCTGATCGAG
ACCCACGAACGGGCACGGCCACGGCAACTGAACCAGTTCCAGCAGCTCAACTCGGCGATCATCTCCGGCTTCCCCATCGTCAGCATGGGC
GAGGCCATCGAGACGGTTCAGCAGATCGCCCGCGAGGAAGCCCCGCGTGGCTTCGCCGTCGACTACGCCGGCGCTTCCCGGCAATACGTG
CAGGAAGGCAGCGCATTGCTGGTCACCTTCGGACTGGCCCTGGCGATCATCTTCCTGGTCCTCGCCGCACAGTTCGAAAGCTTCCGCGAT
CCGCTGGTGATCATGGTCACCGTGCCGCTGTCGATCTGCGGTGCGCTGATACCGCTGTTCCTCGGCGTGTCGAGCCTGAACATCTATACC
CAGGTCGGCCTGGTGACCCTGATCGGCCTGATCAGCAAACACGGCATCCTGATCGTCGAGTTCGCCAACCAGTTGCGCCACGAACAGGGG
CTGGGGCGTCGCGAGGCCATCGAGCAGGCCGCCGCGATCCGCCTGCGGCCAGTACTGATGACCACCGCGGCGATGGTGCTCGGGGTGATC
CCGCTGATCCTCGCCACCGGCGCCGGGGCGGTCAGTCGCTTCGACATCGGCATCGTGATCGCGACCGGCATGTCGGTGGGCACCCTCTTC
ACCCTGTTCGTCCTGCCGTGCATCTACACCCTGGTGGCCAGGCCGGATGCCCCGCCAGGCGTGACGCAAGCGGCAAACGCACACTGA