| Accession | ARO:3003922 |
| CARD Short Name | oqxA |
| Definition | RND efflux pump conferring resistance to fluoroquinolone. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic, diaminopyrimidine antibiotic, glycylcycline, nitrofuran antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Citrobacter freundiiwgs, Enterobacter hormaecheip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogenesg, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Salmonella entericag+p+wgs, Shigella dysenteriaeg, Shigella flexnerip+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Citrobacter amalonaticusg+wgs, Citrobacter freundiiwgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenuswgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatawgs, Salmonella entericag+p+wgs, Shigella dysenteriaeg, Shigella flexnerip+wgs, Shigella sonneiwgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + tetracycline antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + diaminopyrimidine antibiotic [Drug Class] + glycylcycline [Drug Class] + nitrofuran antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + fluoroquinolone antibiotic [Drug Class] + trimethoprim [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + ciprofloxacin [Antibiotic] + tigecycline [Antibiotic] + nitrofurantoin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Kim HB, et al. 2009. Antimicrob. Agents Chemother. 53(8):3582-4 oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. (PMID 19528276) |
Prevalence of oqxA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter amalonaticus | 90.91% | 0% | 70.91% | 0% |
| Citrobacter freundii | 0% | 0% | 0.19% | 0% |
| Enterobacter asburiae | 83.87% | 0% | 68.38% | 0% |
| Enterobacter cancerogenus | 0% | 0% | 14.29% | 0% |
| Enterobacter chengduensis | 100% | 0% | 84% | 0% |
| Enterobacter cloacae | 91.07% | 0% | 66.13% | 0% |
| Enterobacter hormaechei | 93.17% | 0.06% | 62.49% | 0% |
| Enterobacter kobei | 100% | 0% | 66.81% | 0% |
| Enterobacter roggenkampii | 83.72% | 0% | 55.4% | 0% |
| Escherichia albertii | 0% | 0.56% | 1.29% | 0% |
| Escherichia coli | 0.1% | 0.68% | 2.52% | 0% |
| Escherichia fergusonii | 0% | 0.36% | 4.35% | 0% |
| Klebsiella aerogenes | 98% | 0% | 79.38% | 0% |
| Klebsiella michiganensis | 96.77% | 0% | 65.96% | 0% |
| Klebsiella oxytoca | 100% | 0% | 71.85% | 0% |
| Klebsiella pneumoniae | 84.2% | 0.06% | 53.32% | 0% |
| Klebsiella quasipneumoniae | 92.44% | 0% | 65% | 0% |
| Kosakonia arachidis | 100% | 0% | 100% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 2.33% | 0% |
| Salmonella enterica | 0.69% | 3.56% | 0.93% | 0% |
| Shigella dysenteriae | 14.29% | 0% | 0% | 0% |
| Shigella flexneri | 0% | 2.41% | 0.31% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 670