Accession | ARO:3003922 |
CARD Short Name | oqxA |
Definition | RND efflux pump conferring resistance to fluoroquinolone. |
AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
Drug Class | tetracycline antibiotic, diaminopyrimidine antibiotic, glycylcycline, fluoroquinolone antibiotic, nitrofuran antibiotic |
Resistance Mechanism | antibiotic efflux |
Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
Resistomes with Perfect Matches | Citrobacter freundiiwgs, Enterobacter hormaecheip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogenesg, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Salmonella entericag+p+wgs, Shigella sonneiwgs |
Resistomes with Sequence Variants | Acinetobacter baumanniip+wgs, Bacillus subtiliswgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiiwgs, Enterobacter asburiaeg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Salmonella entericag+p+wgs, Shigella sonneiwgs |
Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + tetracycline antibiotic [Drug Class] + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + diaminopyrimidine antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + glycylcycline [Drug Class] + fluoroquinolone antibiotic [Drug Class] + nitrofuran antibiotic [Drug Class] + nitrofurantoin [Antibiotic] + trimethoprim [Antibiotic] + ciprofloxacin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + tigecycline [Antibiotic] |
Parent Term(s) | 2 ontology terms | Show |
Publications | Kim HB, et al. 2009. Antimicrob. Agents Chemother. 53(8):3582-4 oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. (PMID 19528276) |
Prevalence of oqxA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
---|---|---|---|---|
Acinetobacter baumannii | 0% | 0.06% | 0.06% | 0% |
Bacillus subtilis | 0% | 0% | 0.34% | 0% |
Citrobacter amalonaticus | 90% | 0% | 72.92% | 0% |
Citrobacter freundii | 0% | 0% | 0.25% | 0% |
Enterobacter asburiae | 85.71% | 0% | 84.72% | 0% |
Enterobacter chengduensis | 100% | 0% | 90.91% | 0% |
Enterobacter cloacae | 93.18% | 0% | 74.55% | 0% |
Enterobacter hormaechei | 92.26% | 0.17% | 74.69% | 0% |
Enterobacter kobei | 91.67% | 0% | 84.43% | 0% |
Enterobacter roggenkampii | 76.92% | 0% | 66.06% | 0% |
Escherichia albertii | 0% | 2.63% | 1.15% | 0% |
Escherichia coli | 0.09% | 0.57% | 2.83% | 0% |
Escherichia fergusonii | 0% | 0.4% | 6.15% | 0% |
Klebsiella aerogenes | 100% | 0% | 80.82% | 0% |
Klebsiella michiganensis | 93.02% | 0% | 72.08% | 0% |
Klebsiella oxytoca | 100% | 0% | 78.8% | 0% |
Klebsiella pneumoniae | 87.24% | 0.07% | 67.12% | 0% |
Klebsiella quasipneumoniae | 92.86% | 0% | 70.61% | 0% |
Kosakonia arachidis | 100% | 0% | 100% | 0% |
Salmonella enterica | 0.46% | 2.49% | 1.05% | 0% |
Shigella sonnei | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 670