| Accession | ARO:3003706 |
| Definition | Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur. |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 19 ontology terms | Show + faropenem [Antibiotic] + ticarcillin [Antibiotic] + KHM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MdsABC confers_resistance_to_drug_class + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] confers_resistance_to_drug_class + Outer Membrane Porin (Opr) [AMR Gene Family] confers_resistance_to_drug_class + IMP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + GIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + TEM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LEN beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OCH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + VIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_drug_class + MexAB-OprM confers_resistance_to_drug_class + LAP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A Bacillus cereus Bc beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A Mycobacterium abscessus beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + class A Mycobacterium tuberculosis bla beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | McCombie SW, et al. . Med Res Rev 8(3):393-440 Synthesis and in vitro activity of the penem antibiotics. (PMID 3043117) Hamilton-Miller JM, et al. 2003. Pharmacotherapy 23(11):1497-507 Chemical and microbiologic aspects of penems, a distinct class of beta-lactams: focus on faropenem. (PMID 14620395) |