penem [Drug Class]

Accession ARO:3003706
DefinitionPenems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
15 ontology terms | Show
+ faropenem [Antibiotic]
+ ticarcillin [Antibiotic]
+ KHM beta-latamase [AMR Gene Family] confers_resistance_to_drug_class
+ MdsABC confers_resistance_to_drug_class
+ General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] confers_resistance_to_drug_class
+ Outer Membrane Porin (Opr) [AMR Gene Family] confers_resistance_to_drug_class
+ IMP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ GIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ PER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ TEM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ LEN beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ OCH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ VIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_drug_class
+ MexAB-OprM confers_resistance_to_drug_class
Publications

McCombie SW, et al. . Med Res Rev 8(3):393-440 Synthesis and in vitro activity of the penem antibiotics. (PMID 3043117)

Hamilton-Miller JM, et al. 2003. Pharmacotherapy 23(11):1497-507 Chemical and microbiologic aspects of penems, a distinct class of beta-lactams: focus on faropenem. (PMID 14620395)