MexAB-OprM with MexR mutations confers resistance to multiple antibiotics

Accession ARO:3004080
DefinitionMexAB-OprM efflux pump system with MexR mutations confers resistance to multiple antibiotics in P. aeruginosa.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, tetracycline antibiotic, sulfonamide antibiotic, penam, diaminopyrimidine antibiotic, cephalosporin, phenicol antibiotic, carbapenem, antibacterial free fatty acids, aminocoumarin antibiotic, macrolide antibiotic, acridine dye, triclosan, fluoroquinolone antibiotic, monobactam, aminoglycoside antibiotic, glycylcycline, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification55 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ beta-lactam antibiotic
+ lipopeptide antibiotic
+ resistance-modifying agents
+ mechanism of antibiotic resistance
+ cephem
+ antibiotic efflux [Resistance Mechanism]
+ polymyxin antibiotic
+ tetracycline antibiotic [Drug Class]
+ determinant of antibiotic resistance
+ sulfonamide antibiotic [Drug Class]
+ penam [Drug Class]
+ antibiotic without defined classification
+ beta-lactamase inhibitor
+ diaminopyrimidine antibiotic [Drug Class]
+ cephalosporin [Drug Class]
+ phenicol antibiotic [Drug Class]
+ carbapenem [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ colistin
+ antibacterial free fatty acids [Drug Class]
+ clavulanic acid [Adjuvant]
+ antibiotic mixture
+ aminocoumarin antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ acridine dye [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ triclosan [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ monobactam [Drug Class]
+ aminoglycoside antibiotic [Drug Class]
+ glycylcycline [Drug Class]
+ amoxicillin [Antibiotic]
+ trimethoprim [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ aztreonam [Antibiotic]
+ colistin A [Antibiotic]
+ erythromycin [Antibiotic]
+ penem [Drug Class]
+ meropenem [Antibiotic]
+ chloramphenicol [Antibiotic]
+ ampicillin [Antibiotic]
+ azithromycin [Antibiotic]
+ ceftazidime [Antibiotic]
+ ceftriaxone [Antibiotic]
+ novobiocin [Antibiotic]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ panipenem [Antibiotic]
+ amoxicillin-clavulanic acid
+ colistin B [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ tetracycline [Antibiotic]
+ cephamycin [Drug Class]
Parent Term(s)20 ontology terms | Show
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ MexAB-OprM
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin-clavulanic acid
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic panipenem [Antibiotic]
+ confers_resistance_to_antibiotic meropenem [Antibiotic]
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ confers_resistance_to_antibiotic novobiocin [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
+ confers_resistance_to_drug_class sulfonamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class penem [Drug Class]
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ MexA part_of
+ MexB part_of
+ OprM part_of
+ MexR part_of
Publications

Srikumar R, et al. 1998. Antimicrob Agents Chemother 42(1): 65-71. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. (PMID 9449262)

Nehme D and Poole K. 2007. J Bacteriol 189(17): 6118-6127. Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors. (PMID 17586626)

Resistomes

Prevalence of MexAB-OprM with MexR mutations confers resistance to multiple antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexAB-OprM with MexR mutations conferring resistance to multiple antibiotics

Model Description: MexAB-OprM meta-model represents the efflux pump with its regulator, MexR. It holds the MexR model that will detect for the presence of MexR with and without mutations.

OprMmexRMexBMexA