| Accession | ARO:3004080 |
| CARD Short Name | Paer_MexR_MULT |
| Definition | MexAB-OprM efflux pump system with MexR mutations confers resistance to multiple antibiotics in P. aeruginosa. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | peptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, penicillin beta-lactam, cephalosporin, phenicol antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 43 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + lipopeptide antibiotic + beta-lactam antibiotic + mechanism of antibiotic resistance + sulfonamide antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + penicillin beta-lactam [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + cephalosporin [Drug Class] + polymyxin antibiotic + penicillin with extended spectrum + third-generation cephalosporin + antibiotic mixture + phenicol antibiotic [Drug Class] + sulfamethoxazole [Antibiotic] + trimethoprim [Antibiotic] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + colistin + carbapenem [Drug Class] + monobactam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + trimethoprim-sulfamethoxazole [Antibiotic] + panipenem [Antibiotic] + ampicillin [Antibiotic] + colistin B [Antibiotic] + colistin A [Antibiotic] + aztreonam [Antibiotic] + chloramphenicol [Antibiotic] + azithromycin [Antibiotic] + novobiocin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + meropenem [Antibiotic] + ceftriaxone [Antibiotic] + ceftazidime [Antibiotic] + tetracycline [Antibiotic] + ciprofloxacin [Antibiotic] + erythromycin [Antibiotic] |
| Parent Term(s) | 18 ontology terms | Show + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic meropenem [Antibiotic] + confers_resistance_to_antibiotic novobiocin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_drug_class sulfonamide antibiotic [Drug Class] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + MexAB-OprM + confers_resistance_to_antibiotic aztreonam [Antibiotic] + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_antibiotic panipenem [Antibiotic] + confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic] |
| Sub-Term(s) | 4 ontology terms | Show |
| Publications | Srikumar R, et al. 1998. Antimicrob Agents Chemother 42(1): 65-71. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. (PMID 9449262) Nehme D and Poole K. 2007. J Bacteriol 189(17): 6118-6127. Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors. (PMID 17586626) |
Prevalence of MexAB-OprM with MexR mutations confers resistance to multiple antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| No prevalence data | |||||
| Curator | Description | Most Recent Edit |
|---|