OprA

Accession ARO:3003039
CARD Short NameOprA
DefinitionOprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminoglycoside antibiotic, fluoroquinolone antibiotic, macrolide antibiotic, tetracycline antibiotic, carbapenem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesPseudomonas aeruginosawgs
Resistomes with Sequence VariantsPseudomonas aeruginosawgs
Classification25 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Morita Y, et al. 2012. Microbiology 158(PT 4): 1071-1083. Primary mechanisms mediating aminoglycoside resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7. (PMID 22282519)

Resistomes

Prevalence of OprA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Pseudomonas aeruginosa0%0%0.03%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 890


>gb|BAM10414.1|+|OprA [Pseudomonas aeruginosa]
MPLSKLSASSLALCLGLLGACSLAPRYQRPEAPIPTTYPAVPASQQAGDRARLDDWQQQFTDPVLRQMIGQALEHNRNLRVAALRIEEAR
ALYGVQASERLPTLEASGRYERERMRGETREAGEVEQRYRVAAGISAFELDFFGRVKNLGDAALADYLASEEAQRSARIALIAEVAGGYV
QERALYAQQRLAERTLHARENGLALVRKRYAAGMSTRIDLRSEEMLVESARATHAALVRERSQAVSGLQLLLGDFTGDWQDSQLDLEHLQ
LQPLPAGLPSELLARRPDIRQAEQQLRAANANIGAARAAFFPSLRLSTDLGSASSGLHGLFRGGSRVWTFSPQMTLPIFDGGRNRANLDL
AEVRKDIAVNRYEESIQVAFREVADALSAGDQLELQLRAQRAVRDADRERLQLVRKRYAKGVANYLEMLDAQRSLFDSEQQLIHLRGLRL
NNGVALYRALGGGWSQG


>gb|AB639410.1|+|1-1404|OprA [Pseudomonas aeruginosa]
ATGCCCCTTTCGAAACTCTCGGCCTCCTCCCTGGCGCTGTGCCTGGGCCTGCTCGGCGCCTGTTCGCTGGCGCCCCGCTACCAGCGCCCG
GAGGCGCCGATCCCGACGACCTATCCGGCCGTCCCGGCGAGCCAGCAGGCTGGCGACCGGGCCAGGCTGGACGACTGGCAACAACAGTTC
ACCGACCCGGTGCTGCGCCAGATGATCGGCCAGGCCCTGGAGCACAACCGCAACCTGCGCGTCGCCGCCCTGCGCATCGAGGAAGCCCGC
GCGCTATATGGCGTACAGGCCTCGGAGCGCTTGCCGACGCTGGAGGCCAGCGGTCGCTACGAGCGCGAGCGCATGCGCGGCGAAACCCGC
GAGGCCGGCGAGGTCGAACAACGCTATCGGGTCGCAGCCGGCATCAGCGCCTTCGAGCTGGACTTCTTCGGCCGGGTGAAAAACCTCGGC
GACGCCGCCCTGGCCGACTACCTGGCCAGCGAGGAGGCCCAGCGCAGCGCGCGGATCGCCCTGATCGCCGAGGTCGCCGGCGGCTACGTG
CAGGAACGGGCGCTGTACGCACAGCAACGGCTGGCGGAACGCACCCTGCACGCGCGGGAAAACGGCCTGGCGCTGGTGCGCAAGCGCTAC
GCCGCCGGGATGAGCACGCGCATCGACCTGCGCAGCGAGGAAATGCTGGTGGAAAGCGCCCGCGCCACCCACGCCGCGCTGGTTCGCGAA
CGCAGCCAGGCGGTCAGCGGTCTGCAGCTGCTGCTCGGCGACTTCACCGGCGACTGGCAGGATAGCCAGCTGGACCTGGAACACCTCCAG
CTGCAGCCACTGCCCGCCGGACTGCCCTCGGAGCTGCTCGCGCGGCGTCCGGACATCCGCCAGGCCGAACAACAACTGCGCGCGGCCAAC
GCCAACATCGGCGCGGCGCGCGCGGCGTTCTTCCCGAGCCTGCGCCTGAGCACCGACCTGGGCTCGGCCAGTTCAGGCCTGCACGGCCTG
TTCAGGGGCGGCAGCCGGGTCTGGACCTTCAGCCCGCAGATGACCCTGCCGATCTTCGACGGCGGACGCAACCGCGCCAATCTCGACCTC
GCCGAAGTGCGCAAGGACATCGCCGTCAACCGCTACGAGGAAAGCATCCAGGTCGCCTTCCGCGAGGTCGCCGACGCGCTCAGCGCCGGC
GACCAGCTGGAGCTCCAGCTGCGCGCGCAGCGCGCTGTCCGCGACGCCGACCGTGAACGCCTGCAACTGGTACGCAAGCGCTATGCCAAG
GGTGTCGCCAATTACCTGGAAATGCTCGACGCCCAGCGCAGCCTGTTCGACTCGGAACAGCAACTGATCCACCTGCGGGGCCTGCGCCTG
AACAATGGCGTCGCCCTCTATCGCGCCCTCGGCGGCGGCTGGTCGCAAGGCTGA