OprA

Accession ARO:3003039
DefinitionOprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, carbapenem, fluoroquinolone antibiotic, acridine dye, monobactam, aminocoumarin antibiotic, triclosan, aminoglycoside antibiotic, antibacterial free fatty acids, penam, phenicol antibiotic, macrolide antibiotic, glycylcycline, diaminopyrimidine antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification34 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Resistomes

Prevalence of OprA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 890


>gb|BAM10414.1|+|oprA [Pseudomonas aeruginosa]
MPLSKLSASSLALCLGLLGACSLAPRYQRPEAPIPTTYPAVPASQQAGDRARLDDWQQQFTDPVLRQMIGQALEHNRNLRVAALRIEEAR
ALYGVQASERLPTLEASGRYERERMRGETREAGEVEQRYRVAAGISAFELDFFGRVKNLGDAALADYLASEEAQRSARIALIAEVAGGYV
QERALYAQQRLAERTLHARENGLALVRKRYAAGMSTRIDLRSEEMLVESARATHAALVRERSQAVSGLQLLLGDFTGDWQDSQLDLEHLQ
LQPLPAGLPSELLARRPDIRQAEQQLRAANANIGAARAAFFPSLRLSTDLGSASSGLHGLFRGGSRVWTFSPQMTLPIFDGGRNRANLDL
AEVRKDIAVNRYEESIQVAFREVADALSAGDQLELQLRAQRAVRDADRERLQLVRKRYAKGVANYLEMLDAQRSLFDSEQQLIHLRGLRL
NNGVALYRALGGGWSQG


>gb|AB639410|+|1-1404|oprA [Pseudomonas aeruginosa]
ATGCCCCTTTCGAAACTCTCGGCCTCCTCCCTGGCGCTGTGCCTGGGCCTGCTCGGCGCCTGTTCGCTGGCGCCCCGCTACCAGCGCCCG
GAGGCGCCGATCCCGACGACCTATCCGGCCGTCCCGGCGAGCCAGCAGGCTGGCGACCGGGCCAGGCTGGACGACTGGCAACAACAGTTC
ACCGACCCGGTGCTGCGCCAGATGATCGGCCAGGCCCTGGAGCACAACCGCAACCTGCGCGTCGCCGCCCTGCGCATCGAGGAAGCCCGC
GCGCTATATGGCGTACAGGCCTCGGAGCGCTTGCCGACGCTGGAGGCCAGCGGTCGCTACGAGCGCGAGCGCATGCGCGGCGAAACCCGC
GAGGCCGGCGAGGTCGAACAACGCTATCGGGTCGCAGCCGGCATCAGCGCCTTCGAGCTGGACTTCTTCGGCCGGGTGAAAAACCTCGGC
GACGCCGCCCTGGCCGACTACCTGGCCAGCGAGGAGGCCCAGCGCAGCGCGCGGATCGCCCTGATCGCCGAGGTCGCCGGCGGCTACGTG
CAGGAACGGGCGCTGTACGCACAGCAACGGCTGGCGGAACGCACCCTGCACGCGCGGGAAAACGGCCTGGCGCTGGTGCGCAAGCGCTAC
GCCGCCGGGATGAGCACGCGCATCGACCTGCGCAGCGAGGAAATGCTGGTGGAAAGCGCCCGCGCCACCCACGCCGCGCTGGTTCGCGAA
CGCAGCCAGGCGGTCAGCGGTCTGCAGCTGCTGCTCGGCGACTTCACCGGCGACTGGCAGGATAGCCAGCTGGACCTGGAACACCTCCAG
CTGCAGCCACTGCCCGCCGGACTGCCCTCGGAGCTGCTCGCGCGGCGTCCGGACATCCGCCAGGCCGAACAACAACTGCGCGCGGCCAAC
GCCAACATCGGCGCGGCGCGCGCGGCGTTCTTCCCGAGCCTGCGCCTGAGCACCGACCTGGGCTCGGCCAGTTCAGGCCTGCACGGCCTG
TTCAGGGGCGGCAGCCGGGTCTGGACCTTCAGCCCGCAGATGACCCTGCCGATCTTCGACGGCGGACGCAACCGCGCCAATCTCGACCTC
GCCGAAGTGCGCAAGGACATCGCCGTCAACCGCTACGAGGAAAGCATCCAGGTCGCCTTCCGCGAGGTCGCCGACGCGCTCAGCGCCGGC
GACCAGCTGGAGCTCCAGCTGCGCGCGCAGCGCGCTGTCCGCGACGCCGACCGTGAACGCCTGCAACTGGTACGCAAGCGCTATGCCAAG
GGTGTCGCCAATTACCTGGAAATGCTCGACGCCCAGCGCAGCCTGTTCGACTCGGAACAGCAACTGATCCACCTGCGGGGCCTGCGCCTG
AACAATGGCGTCGCCCTCTATCGCGCCCTCGGCGGCGGCTGGTCGCAAGGCTGA