| Accession | ARO:0000044 |
| Definition | Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + cephem |
| Sub-Term(s) | 32 ontology terms | Show + cefoxitin [Antibiotic] + cefmetazole [Antibiotic] + cefotetan [Antibiotic] + CAM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + TUS beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + KHM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + AIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MexAB-OprM confers_resistance_to_drug_class + MexXY-OprM confers_resistance_to_drug_class + AcrEF-TolC confers_resistance_to_drug_class + MdsABC confers_resistance_to_drug_class + SmeABC confers_resistance_to_drug_class + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] confers_resistance_to_drug_class + Outer Membrane Porin (Opr) [AMR Gene Family] confers_resistance_to_drug_class + TMB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + IMP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + GIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + DHA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CfxA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + CMY beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ACT beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + FOX beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MOX beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OCH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + VIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics [AMR Gene Family] confers_resistance_to_drug_class + NDM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PJM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + SSA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + LAQ beta lactamase [AMR Gene Family] confers_resistance_to_drug_class + beta-lactam sensitive penicillin-binding protein targeted_by + CMY-2 confers_resistance_to_antibiotic |
| Publications | Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804) Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791) Faraci WS and Pratt RF. 1986. Biochemistry 25(10): 2934-2941. Mechanism of inhibition of RTEM-2 beta-lactamase by cephamycins: relative importance of the 7 alpha-methoxy group and the 3' leaving group. (PMID 3487346) |
