| Accession | ARO:3000815 |
| Synonym(s) | norR |
| CARD Short Name | mgrA |
| Definition | MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump, ATP-binding cassette (ABC) antibiotic efflux pump |
| Drug Class | peptide antibiotic, fluoroquinolone antibiotic, disinfecting agents and antiseptics, tetracycline antibiotic, cephalosporin, penam |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Staphylococcus aureusg+wgs |
| Resistomes with Sequence Variants | Burkholderia vietnamiensiswgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Listeria monocytogeneswgs, Shigella flexneriwgs, Staphylococcus aureusg+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus lugdunensiswgs, Vibrio choleraewgs |
| Classification | 28 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + peptide antibiotic [Drug Class] + beta-lactam antibiotic + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + cephem + lipopeptide antibiotic + fluoroquinolone antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + disinfecting agents and antiseptics [Drug Class] + tetracycline antibiotic [Drug Class] + cephalosporin [Drug Class] + penam [Drug Class] + moenomycin + norfloxacin [Antibiotic] + moxifloxacin [Antibiotic] + ciprofloxacin [Antibiotic] + moenomycin A1 [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + sparfloxacin [Antibiotic] + tetracycline [Antibiotic] + cefotaxime [Antibiotic] + ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family] + acriflavine [Antibiotic] + daptomycin [Antibiotic] + methicillin [Antibiotic] |
| Parent Term(s) | 5 ontology terms | Show + regulates norA + regulates norB + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + regulates tet(38) + regulates abcA |
| Publications | Truong-Bolduc QC, et al. 2003. J Bacteriol 185(10): 3127-3138. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus. (PMID 12730173) Truong-Bolduc QC, et al. 2005. J Bacteriol 187(7): 2395-2405. MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. (PMID 15774883) |
Prevalence of mgrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Burkholderia vietnamiensis | 0% | 0% | 0.86% | 0% |
| Escherichia coli | 0% | 0% | 0.03% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.03% | 0% |
| Shigella flexneri | 0% | 0% | 0.16% | 0% |
| Staphylococcus aureus | 100% | 0% | 58.69% | 0% |
| Staphylococcus capitis | 100% | 0% | 66.01% | 0% |
| Staphylococcus epidermidis | 10.91% | 0% | 13.15% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.44% | 0% |
| Staphylococcus lugdunensis | 0% | 0% | 1.85% | 0% |
| Vibrio cholerae | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 270