| Accession | ARO:3000815 |
| Synonym(s) | norR |
| CARD Short Name | mgrA |
| Definition | MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump, ATP-binding cassette (ABC) antibiotic efflux pump |
| Drug Class | peptide antibiotic, tetracycline antibiotic, penam, fluoroquinolone antibiotic, disinfecting agents and antiseptics, cephalosporin |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Staphylococcus aureusg+wgs |
| Resistomes with Sequence Variants | Escherichia coliwgs, Klebsiella pneumoniaewgs, Listeria monocytogeneswgs, Shigella flexneriwgs, Staphylococcus aureusg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus lugdunensiswgs, Vibrio choleraewgs |
| Classification | 28 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + peptide antibiotic [Drug Class] + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + lipopeptide antibiotic + cephem + tetracycline antibiotic [Drug Class] + penam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + disinfecting agents and antiseptics [Drug Class] + moenomycin + cephalosporin [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + moxifloxacin [Antibiotic] + ciprofloxacin [Antibiotic] + moenomycin A1 [Antibiotic] + sparfloxacin [Antibiotic] + methicillin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + tetracycline [Antibiotic] + cefotaxime [Antibiotic] + ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family] + acriflavine [Antibiotic] + norfloxacin [Antibiotic] + daptomycin [Antibiotic] |
| Parent Term(s) | 5 ontology terms | Show + regulates norA + regulates norB + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + regulates tet(38) + regulates abcA |
| Publications | Truong-Bolduc QC, et al. 2003. J Bacteriol 185(10): 3127-3138. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus. (PMID 12730173) Truong-Bolduc QC, et al. 2005. J Bacteriol 187(7): 2395-2405. MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. (PMID 15774883) |
Prevalence of mgrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia coli | 0% | 0% | 0.03% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.03% | 0% |
| Shigella flexneri | 0% | 0% | 0.16% | 0% |
| Staphylococcus aureus | 99.76% | 0% | 61.02% | 0% |
| Staphylococcus epidermidis | 11.24% | 0% | 13.03% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.6% | 0% |
| Staphylococcus lugdunensis | 0% | 0% | 9.09% | 0% |
| Vibrio cholerae | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 270