MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

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Accession ARO:3004048
CARD Short NamePaer_tMexR_MULT
DefinitionMexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, penam, carbapenem, cephalosporin, phenicol antibiotic, monobactam, fluoroquinolone antibiotic, tetracycline antibiotic, macrolide antibiotic, aminocoumarin antibiotic, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification44 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ beta-lactam antibiotic
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ cephem
+ diaminopyrimidine antibiotic [Drug Class]
+ polymyxin antibiotic
+ determinant of antibiotic resistance
+ antibiotic efflux [Resistance Mechanism]
+ sulfonamide antibiotic [Drug Class]
+ penam [Drug Class]
+ colistin
+ carbapenem [Drug Class]
+ antibiotic mixture
+ cephalosporin [Drug Class]
+ phenicol antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ monobactam [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ trimethoprim [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ aminocoumarin antibiotic [Drug Class]
+ penem [Drug Class]
+ ceftriaxone [Antibiotic]
+ colistin A [Antibiotic]
+ azithromycin [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ panipenem [Antibiotic]
+ cephamycin [Drug Class]
+ aztreonam [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ tetracycline [Antibiotic]
+ erythromycin [Antibiotic]
+ meropenem [Antibiotic]
+ chloramphenicol [Antibiotic]
+ novobiocin [Antibiotic]
+ ceftazidime [Antibiotic]
+ ampicillin [Antibiotic]
+ colistin B [Antibiotic]
Parent Term(s)3 ontology terms | Show
+ MexAB-OprM
+ confers_resistance_to_antibiotic meropenem [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ MexR part_of
+ MexA part_of
+ MexB part_of
+ OprM part_of
Publications

Choudhury D, et al. 2016. PLoS ONE 11(2):e0149156 Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India. (PMID 26866484)
Resistomes

Prevalence of MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Name: MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

Model Description: This MexAB-OprM efflux system has a prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin.

OprMMexBMexAmexR