MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

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Accession	ARO:3004048
CARD Short Name	Paer_tMexR_MULT
Definition	MexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin.
AMR Gene Family	resistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Class	peptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, penicillin beta-lactam, cephalosporin, phenicol antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanism	antibiotic efflux
Efflux Component	efflux pump complex or subunit conferring antibiotic resistance
Classification	43 ontology terms \| Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + lipopeptide antibiotic + beta-lactam antibiotic + mechanism of antibiotic resistance + sulfonamide antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + penicillin beta-lactam [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + cephalosporin [Drug Class] + polymyxin antibiotic + penicillin with extended spectrum + third-generation cephalosporin + antibiotic mixture + phenicol antibiotic [Drug Class] + sulfamethoxazole [Antibiotic] + trimethoprim [Antibiotic] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + colistin + carbapenem [Drug Class] + monobactam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + trimethoprim-sulfamethoxazole [Antibiotic] + panipenem [Antibiotic] + ampicillin [Antibiotic] + colistin B [Antibiotic] + colistin A [Antibiotic] + aztreonam [Antibiotic] + chloramphenicol [Antibiotic] + azithromycin [Antibiotic] + novobiocin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + meropenem [Antibiotic] + ceftriaxone [Antibiotic] + ceftazidime [Antibiotic] + tetracycline [Antibiotic] + ciprofloxacin [Antibiotic] + erythromycin [Antibiotic]
Parent Term(s)	3 ontology terms \| Show + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic meropenem [Antibiotic] + MexAB-OprM
Sub-Term(s)	4 ontology terms \| Show + MexR part_of + MexA part_of + MexB part_of + OprM part_of
Publications	Choudhury D, et al. 2016. PLoS ONE 11(2):e0149156 Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India. (PMID 26866484)

Resistomes

Prevalence of MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

Species	NCBI Chromosome	NCBI Plasmid	NCBI WGS	NCBI GI	GRDI-AMR2
No prevalence data

Detection Models

efflux pump system meta-model

Model Name: MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

Model Description: This MexAB-OprM efflux system has a prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin.

OprMMexBMexAmexR

Curator Acknowledgements

Curator	Description	Most Recent Edit

MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

Prevalence: efflux pump system meta-model

Graph