MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

Accession ARO:3004048
CARD Short NamePaer_tMexR_MULT
DefinitionMexAB-OprM efflux pump system with a prematurely terminated MexR confers resistance to meropenem and ciprofloxacin.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, sulfonamide antibiotic, penam, diaminopyrimidine antibiotic, carbapenem, tetracycline antibiotic, phenicol antibiotic, macrolide antibiotic, cephalosporin, aminocoumarin antibiotic, monobactam, fluoroquinolone antibiotic, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification51 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ resistance-modifying agents
+ peptide antibiotic [Drug Class]
+ beta-lactamase inhibitor
+ beta-lactam antibiotic
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ serine beta-lactamase inhibitor
+ cephem
+ sulfonamide antibiotic [Drug Class]
+ penam [Drug Class]
+ polymyxin antibiotic
+ diaminopyrimidine antibiotic [Drug Class]
+ antibiotic efflux [Resistance Mechanism]
+ determinant of antibiotic resistance
+ beta-lactam derived beta-lactamase inhibitor
+ carbapenem [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ tetracycline antibiotic [Drug Class]
+ clavulanic acid [Adjuvant]
+ phenicol antibiotic [Drug Class]
+ amoxicillin [Antibiotic]
+ trimethoprim [Antibiotic]
+ macrolide antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ antibiotic mixture
+ cephalosporin [Drug Class]
+ aminocoumarin antibiotic [Drug Class]
+ colistin
+ monobactam [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ penem [Drug Class]
+ ceftriaxone [Antibiotic]
+ colistin A [Antibiotic]
+ meropenem [Antibiotic]
+ panipenem [Antibiotic]
+ aztreonam [Antibiotic]
+ novobiocin [Antibiotic]
+ amoxicillin-clavulanic acid [Antibiotic+Adjuvant]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ ciprofloxacin [Antibiotic]
+ azithromycin [Antibiotic]
+ erythromycin [Antibiotic]
+ tetracycline [Antibiotic]
+ chloramphenicol [Antibiotic]
+ ceftazidime [Antibiotic]
+ ampicillin [Antibiotic]
+ colistin B [Antibiotic]
+ cephamycin [Drug Class]
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic meropenem [Antibiotic]
+ MexAB-OprM
Sub-Term(s)
4 ontology terms | Show
+ MexR part_of
+ MexA part_of
+ MexB part_of
+ OprM part_of
Publications

Choudhury D, et al. 2016. PLoS ONE 11(2):e0149156 Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India. (PMID 26866484)

Resistomes

Prevalence of MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Name: MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin

Model Description: This MexAB-OprM efflux system has a prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin.

OprMMexBMexAmexR