| Accession | ARO:3004051 |
| CARD Short Name | Paer_NalC_ATM |
| Definition | MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | peptide antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic, macrolide antibiotic, carbapenem, aminocoumarin antibiotic, tetracycline antibiotic, cephalosporin, monobactam, fluoroquinolone antibiotic, penam, cephamycin, penem |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 44 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + beta-lactam antibiotic + lipopeptide antibiotic + mechanism of antibiotic resistance + determinant of antibiotic resistance + cephem + polymyxin antibiotic + diaminopyrimidine antibiotic [Drug Class] + antibiotic efflux [Resistance Mechanism] + sulfonamide antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + carbapenem [Drug Class] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + cephalosporin [Drug Class] + antibiotic mixture + trimethoprim [Antibiotic] + colistin + monobactam [Drug Class] + sulfamethoxazole [Antibiotic] + fluoroquinolone antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + penam [Drug Class] + tetracycline [Antibiotic] + meropenem [Antibiotic] + ceftriaxone [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + trimethoprim-sulfamethoxazole [Antibiotic] + ampicillin [Antibiotic] + colistin A [Antibiotic] + ceftazidime [Antibiotic] + panipenem [Antibiotic] + cephamycin [Drug Class] + azithromycin [Antibiotic] + penem [Drug Class] + novobiocin [Antibiotic] + chloramphenicol [Antibiotic] + ciprofloxacin [Antibiotic] + aztreonam [Antibiotic] + erythromycin [Antibiotic] + colistin B [Antibiotic] |
| Parent Term(s) | 9 ontology terms | Show + MexAB-OprM + confers_resistance_to_antibiotic aztreonam [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_antibiotic meropenem [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
| Sub-Term(s) | 4 ontology terms | Show |
| Publications | Braz VS, et al. 2016. FEMS Microbiol. Lett. : Mutations in NalC induce MexAB-OprM overexpression resulting in high level of aztreonam resistance in environmental isolates of Pseudomonas aeruginosa. (PMID 27412168) Cao L, et al. 2004. Mol Microbiol 53(5): 1423-1436. MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. (PMID 15387820) |
Prevalence of MexAB-OprM with NalC mutations conferring resistance to aztreonam among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: MexAB-OprM with NalC mutations conferring resistance to aztreonam
Model Description: MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains.
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