MexAB-OprM with NalC mutations conferring resistance to aztreonam

Accession ARO:3004051
CARD Short NamePaer_NalC_ATM
DefinitionMexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, penam, aminocoumarin antibiotic, macrolide antibiotic, carbapenem, cephalosporin, monobactam, phenicol antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification51 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ resistance-modifying agents
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ beta-lactamase inhibitor
+ mechanism of antibiotic resistance
+ beta-lactam antibiotic
+ serine beta-lactamase inhibitor
+ lipopeptide antibiotic
+ cephem
+ diaminopyrimidine antibiotic [Drug Class]
+ beta-lactam derived beta-lactamase inhibitor
+ antibiotic efflux [Resistance Mechanism]
+ determinant of antibiotic resistance
+ sulfonamide antibiotic [Drug Class]
+ polymyxin antibiotic
+ penam [Drug Class]
+ aminocoumarin antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ colistin
+ carbapenem [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ cephalosporin [Drug Class]
+ monobactam [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ trimethoprim [Antibiotic]
+ antibiotic mixture
+ phenicol antibiotic [Drug Class]
+ clavulanic acid [Adjuvant]
+ tetracycline antibiotic [Drug Class]
+ amoxicillin [Antibiotic]
+ fluoroquinolone antibiotic [Drug Class]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ ceftriaxone [Antibiotic]
+ chloramphenicol [Antibiotic]
+ novobiocin [Antibiotic]
+ erythromycin [Antibiotic]
+ tetracycline [Antibiotic]
+ meropenem [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ ciprofloxacin [Antibiotic]
+ colistin A [Antibiotic]
+ ceftazidime [Antibiotic]
+ penem [Drug Class]
+ cephamycin [Drug Class]
+ panipenem [Antibiotic]
+ azithromycin [Antibiotic]
+ aztreonam [Antibiotic]
+ ampicillin [Antibiotic]
+ colistin B [Antibiotic]
+ amoxicillin-clavulanic acid [Antibiotic+Adjuvant]
Parent Term(s)10 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ confers_resistance_to_antibiotic meropenem [Antibiotic]
+ MexAB-OprM
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin-clavulanic acid [Antibiotic+Adjuvant]
+ confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ OprM part_of
+ MexA part_of
+ MexB part_of
+ nalC part_of
Publications

Braz VS, et al. 2016. FEMS Microbiol. Lett. : Mutations in NalC induce MexAB-OprM overexpression resulting in high level of aztreonam resistance in environmental isolates of Pseudomonas aeruginosa. (PMID 27412168)

Cao L, et al. 2004. Mol Microbiol 53(5): 1423-1436. MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. (PMID 15387820)

Resistomes

Prevalence of MexAB-OprM with NalC mutations conferring resistance to aztreonam among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Name: MexAB-OprM with NalC mutations conferring resistance to aztreonam

Model Description: MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains.

OprMMexBMexAnalC