MexAB-OprM with NalC mutations conferring resistance to aztreonam

Accession ARO:3004051
DefinitionMexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, diaminopyrimidine antibiotic, tetracycline antibiotic, penam, sulfonamide antibiotic, glycylcycline, cephalosporin, monobactam, triclosan, aminocoumarin antibiotic, phenicol antibiotic, antibacterial free fatty acids, macrolide antibiotic, aminoglycoside antibiotic, acridine dye, fluoroquinolone antibiotic, carbapenem, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification55 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ beta-lactam antibiotic
+ lipopeptide antibiotic
+ mechanism of antibiotic resistance
+ resistance-modifying agents
+ determinant of antibiotic resistance
+ polymyxin antibiotic
+ antibiotic efflux [Resistance Mechanism]
+ cephem
+ diaminopyrimidine antibiotic [Drug Class]
+ tetracycline antibiotic [Drug Class]
+ penam [Drug Class]
+ antibiotic without defined classification
+ beta-lactamase inhibitor
+ sulfonamide antibiotic [Drug Class]
+ colistin
+ glycylcycline [Drug Class]
+ trimethoprim [Antibiotic]
+ cephalosporin [Drug Class]
+ amoxicillin [Antibiotic]
+ monobactam [Drug Class]
+ antibiotic mixture
+ triclosan [Drug Class]
+ aminocoumarin antibiotic [Drug Class]
+ phenicol antibiotic [Drug Class]
+ antibacterial free fatty acids [Drug Class]
+ macrolide antibiotic [Drug Class]
+ aminoglycoside antibiotic [Drug Class]
+ acridine dye [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ carbapenem [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ clavulanic acid [Adjuvant]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ tetracycline [Antibiotic]
+ ceftriaxone [Antibiotic]
+ meropenem [Antibiotic]
+ colistin A [Antibiotic]
+ ceftazidime [Antibiotic]
+ amoxicillin-clavulanic acid
+ panipenem [Antibiotic]
+ colistin B [Antibiotic]
+ penem [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ aztreonam [Antibiotic]
+ azithromycin [Antibiotic]
+ novobiocin [Antibiotic]
+ chloramphenicol [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ ampicillin [Antibiotic]
+ erythromycin [Antibiotic]
+ cephamycin [Drug Class]
Parent Term(s)10 ontology terms | Show
+ MexAB-OprM
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin-clavulanic acid
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic meropenem [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ OprM part_of
+ MexA part_of
+ MexB part_of
+ nalC part_of
Publications

Braz VS, et al. 2016. FEMS Microbiol. Lett. : Mutations in NalC induce MexAB-OprM overexpression resulting in high level of aztreonam resistance in environmental isolates of Pseudomonas aeruginosa. (PMID 27412168)

Cao L, et al. 2004. Mol Microbiol 53(5): 1423-1436. MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. (PMID 15387820)

Resistomes

Prevalence of MexAB-OprM with NalC mutations conferring resistance to aztreonam among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexAB-OprM with NalC mutations conferring resistance to aztreonam

Model Description: MexAB-OprM efflux pump system with NalC mutations conferring resistance to aztreonam. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also occurs independently of mexR mutations in so-called nalC mutants that demonstrate more modest mexAB-oprM expression and, thus, more modest multidrug resistance than do mexR strains.

OprMMexBMexAnalC