MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam

Accession ARO:3004053
DefinitionCpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, tetracycline antibiotic, penam, triclosan, carbapenem, monobactam, phenicol antibiotic, macrolide antibiotic, antibacterial free fatty acids, aminocoumarin antibiotic, fluoroquinolone antibiotic, cephalosporin, aminoglycoside antibiotic, acridine dye, glycylcycline, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification55 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ resistance-modifying agents
+ beta-lactam antibiotic
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ determinant of antibiotic resistance
+ sulfonamide antibiotic [Drug Class]
+ cephem
+ diaminopyrimidine antibiotic [Drug Class]
+ polymyxin antibiotic
+ tetracycline antibiotic [Drug Class]
+ beta-lactamase inhibitor
+ antibiotic without defined classification
+ antibiotic efflux [Resistance Mechanism]
+ penam [Drug Class]
+ triclosan [Drug Class]
+ carbapenem [Drug Class]
+ monobactam [Drug Class]
+ phenicol antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ antibacterial free fatty acids [Drug Class]
+ amoxicillin [Antibiotic]
+ aminocoumarin antibiotic [Drug Class]
+ clavulanic acid [Adjuvant]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ fluoroquinolone antibiotic [Drug Class]
+ trimethoprim [Antibiotic]
+ cephalosporin [Drug Class]
+ antibiotic mixture
+ sulfamethoxazole [Antibiotic]
+ colistin
+ aminoglycoside antibiotic [Drug Class]
+ acridine dye [Drug Class]
+ glycylcycline [Drug Class]
+ colistin A [Antibiotic]
+ amoxicillin-clavulanic acid
+ penem [Drug Class]
+ ciprofloxacin [Antibiotic]
+ chloramphenicol [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ceftazidime [Antibiotic]
+ panipenem [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ tetracycline [Antibiotic]
+ cephamycin [Drug Class]
+ colistin B [Antibiotic]
+ aztreonam [Antibiotic]
+ azithromycin [Antibiotic]
+ erythromycin [Antibiotic]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ ampicillin [Antibiotic]
+ novobiocin [Antibiotic]
+ meropenem [Antibiotic]
Parent Term(s)9 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ MexAB-OprM
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin-clavulanic acid
+ confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ MexA part_of
+ MexB part_of
+ OprM part_of
+ Pseudomonas aeruginosa CpxR part_of
Publications

Tian ZX, et al. 2016. PLoS Pathog. 12(10):e1005932 CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa. (PMID 27736975)

Resistomes

Prevalence of MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam

Model Description: CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR.

OprMMexBMexAPseudomonas aeruginosa CpxR