MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics

Accession ARO:3004052
DefinitionMexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, tetracycline antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, penam, cephalosporin, monobactam, aminocoumarin antibiotic, fluoroquinolone antibiotic, antibacterial free fatty acids, carbapenem, triclosan, aminoglycoside antibiotic, glycylcycline, phenicol antibiotic, acridine dye, macrolide antibiotic, cephamycin, penem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification55 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ peptide antibiotic [Drug Class]
+ beta-lactam antibiotic
+ lipopeptide antibiotic
+ mechanism of antibiotic resistance
+ resistance-modifying agents
+ polymyxin antibiotic
+ beta-lactamase inhibitor
+ tetracycline antibiotic [Drug Class]
+ determinant of antibiotic resistance
+ cephem
+ antibiotic efflux [Resistance Mechanism]
+ diaminopyrimidine antibiotic [Drug Class]
+ sulfonamide antibiotic [Drug Class]
+ penam [Drug Class]
+ antibiotic without defined classification
+ cephalosporin [Drug Class]
+ monobactam [Drug Class]
+ aminocoumarin antibiotic [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ antibacterial free fatty acids [Drug Class]
+ carbapenem [Drug Class]
+ triclosan [Drug Class]
+ clavulanic acid [Adjuvant]
+ aminoglycoside antibiotic [Drug Class]
+ antibiotic mixture
+ glycylcycline [Drug Class]
+ amoxicillin [Antibiotic]
+ colistin
+ sulfamethoxazole [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ trimethoprim [Antibiotic]
+ acridine dye [Drug Class]
+ macrolide antibiotic [Drug Class]
+ cephamycin [Drug Class]
+ ceftazidime [Antibiotic]
+ chloramphenicol [Antibiotic]
+ meropenem [Antibiotic]
+ azithromycin [Antibiotic]
+ novobiocin [Antibiotic]
+ panipenem [Antibiotic]
+ aztreonam [Antibiotic]
+ colistin A [Antibiotic]
+ tetracycline [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ penem [Drug Class]
+ ceftriaxone [Antibiotic]
+ ampicillin [Antibiotic]
+ erythromycin [Antibiotic]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ colistin B [Antibiotic]
+ amoxicillin-clavulanic acid
Parent Term(s)12 ontology terms | Show
+ MexAB-OprM
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin-clavulanic acid
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ nalD part_of
+ MexA part_of
+ MexB part_of
+ OprM part_of
Publications

Sobel ML, et al. 2005. Antimicrob Agents Chemother 49(5): 1782-1786. Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa. (PMID 15855496)

Resistomes

Prevalence of MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexAB-OprM with NalD mutation conferring resistance to multiple antibiotics

Model Description: MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC.

OprMMexBMexAnalD