| Accession | ARO:3004052 |
| CARD Short Name | Paer_NalD_MULT |
| Definition | MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | peptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, phenicol antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, penam, cephalosporin, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic, penem, cephamycin |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 44 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + lipopeptide antibiotic + beta-lactam antibiotic + mechanism of antibiotic resistance + sulfonamide antibiotic [Drug Class] + cephem + diaminopyrimidine antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + polymyxin antibiotic + antibiotic mixture + phenicol antibiotic [Drug Class] + sulfamethoxazole [Antibiotic] + trimethoprim [Antibiotic] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + penam [Drug Class] + colistin + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + trimethoprim-sulfamethoxazole [Antibiotic] + panipenem [Antibiotic] + penem [Drug Class] + ampicillin [Antibiotic] + colistin B [Antibiotic] + colistin A [Antibiotic] + aztreonam [Antibiotic] + chloramphenicol [Antibiotic] + azithromycin [Antibiotic] + novobiocin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + meropenem [Antibiotic] + ceftriaxone [Antibiotic] + ceftazidime [Antibiotic] + tetracycline [Antibiotic] + cephamycin [Drug Class] + ciprofloxacin [Antibiotic] + erythromycin [Antibiotic] |
| Parent Term(s) | 11 ontology terms | Show + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + MexAB-OprM + confers_resistance_to_antibiotic aztreonam [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_antibiotic nalidixic acid [Antibiotic] + confers_resistance_to_antibiotic ticarcillin [Antibiotic] + confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic] |
| Sub-Term(s) | 4 ontology terms | Show |
| Publications | Sobel ML, et al. 2005. Antimicrob Agents Chemother 49(5): 1782-1786. Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa. (PMID 15855496) |
Prevalence of MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics
Model Description: MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC.
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