MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics

Accession ARO:3004052
CARD Short NamePaer_NalD_MULT
DefinitionMexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpeptide antibiotic, sulfonamide antibiotic, penam, diaminopyrimidine antibiotic, aminocoumarin antibiotic, phenicol antibiotic, cephalosporin, monobactam, carbapenem, fluoroquinolone antibiotic, macrolide antibiotic, tetracycline antibiotic, penem, cephamycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification51 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ resistance-modifying agents
+ peptide antibiotic [Drug Class]
+ beta-lactamase inhibitor
+ mechanism of antibiotic resistance
+ lipopeptide antibiotic
+ beta-lactam antibiotic
+ serine beta-lactamase inhibitor
+ polymyxin antibiotic
+ determinant of antibiotic resistance
+ sulfonamide antibiotic [Drug Class]
+ penam [Drug Class]
+ cephem
+ beta-lactam derived beta-lactamase inhibitor
+ diaminopyrimidine antibiotic [Drug Class]
+ antibiotic efflux [Resistance Mechanism]
+ aminocoumarin antibiotic [Drug Class]
+ antibiotic mixture
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ amoxicillin [Antibiotic]
+ phenicol antibiotic [Drug Class]
+ colistin
+ cephalosporin [Drug Class]
+ monobactam [Drug Class]
+ trimethoprim [Antibiotic]
+ carbapenem [Drug Class]
+ clavulanic acid [Adjuvant]
+ fluoroquinolone antibiotic [Drug Class]
+ macrolide antibiotic [Drug Class]
+ sulfamethoxazole [Antibiotic]
+ tetracycline antibiotic [Drug Class]
+ colistin A [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ azithromycin [Antibiotic]
+ meropenem [Antibiotic]
+ erythromycin [Antibiotic]
+ penem [Drug Class]
+ ceftriaxone [Antibiotic]
+ cephamycin [Drug Class]
+ ceftazidime [Antibiotic]
+ panipenem [Antibiotic]
+ amoxicillin-clavulanic acid [Antibiotic+Adjuvant]
+ ciprofloxacin [Antibiotic]
+ chloramphenicol [Antibiotic]
+ tetracycline [Antibiotic]
+ ampicillin [Antibiotic]
+ novobiocin [Antibiotic]
+ aztreonam [Antibiotic]
+ trimethoprim-sulfamethoxazole [Antibiotic]
+ colistin B [Antibiotic]
Parent Term(s)12 ontology terms | Show
+ MexAB-OprM
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic]
+ confers_resistance_to_antibiotic ceftriaxone [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin-clavulanic acid [Antibiotic+Adjuvant]
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ nalD part_of
+ MexA part_of
+ MexB part_of
+ OprM part_of
Publications

Sobel ML, et al. 2005. Antimicrob Agents Chemother 49(5): 1782-1786. Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa. (PMID 15855496)

Resistomes

Prevalence of MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Name: MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics

Model Description: MexAB-OprM efflux pump system with a NalD mutation conferring resistance to multiple antibiotics. This NalD mutation was found in multidrug-resistant clinical strains lacking mutations in MexR or NalC.

OprMMexBMexAnalD